I67.3
Conditions
Interventions
Group 1: Dance training (dancing school CreaDom, Mannheim
www.creadom.de): structured training, adopted to the individual level of proficiency (Standard and Latin American dances, modern dance), classes in repetitive sequence, twice per week, each one hour,
www.tsvmannheim.de): cardiovascular training, flexibility, stretching, strengthening
no rhythmical elements, no musical exercise, low proportion of coordinative training. Classes twice per week, each one hour, duration: 12 months.
Group 3: Control group. No sportive activity. Duration
Sponsors
UniversitätsMedizin Mannheim
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. age = 60 years 2. retired (working < 10 hours / week) 3. able to consent 4. no regular physical activity before study inclusion 5. willingness and availability to participate in training during the 12-month period regularly 6. German as native language 7. evidence of a relevant small vessel disease (Fazekas score 1 or higher)
Exclusion criteria
Exclusion criteria: 1. contraindication against magnetic resonance imaging (cardiac pace maker, metal implants, claustrophobia) 2. history of a neurological disease with functional impairment 3. history of a psychiatric disease with functional impairment 4. diagnosis of a dementia or a cognitive impairment relevant for daily life 5. malignancy, life expectancy < 12 months 6. clinically significant cardiac disease, e.g. insufficiency NYHA III / IV, cardiac infarction within six weeks of inclusion, unsuited for sports 7. clinically significant pulmonary disease, e.g. COPD III / IV 8. planned surgical procedure during 12 month study intervention 9. visual or hearing impairment, interfering with neuropsychological testing or fMRI 10. intake of neuroleptics or anti-dementia drugs 11. MoCA = 20 12. MRI evidence of an intracranial hemorrhage, a cortical infarction, a space-occupying lesion, "white matter lesion mimics"
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Course of performance in dual tasks split attention: 1. hand motor speed and visuomotor differentiation (grooved pegboard) / serial subtraction, 2. gait (computer-assisted gait analysis) / counting months backward, 3. gait (computer-assisted gait analysis) / balance (carrying a tablet with a glass filled with water). Analysis: MANOVA, time points: before intervention, after 6 months, after 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychological examination: (each MANOVA) 1. reaction rate (TAP Alertness) 2. selective attention (TAP Go-Nogo) 3. interference control (color-word-test, NAI) 4. task switching (Trail Making Test A+B) 5. hand motor speed and visuomotor differentiation (grooved pegboard) 6. capacity and working memory (WMS-R, Repeating Numbers back and forth) 7. verbal memory (VLMT) 8. visual memory (VVM) 9. word fluency (RWT) 10. figural fluency (5-point-test) 11. spatial imagination (LPS50+: LPS-9) 12. mental rotation (LPS50+: LPS-7) questionnaires: (each MANOVA) 1. depression (ADS-L) 2. self-efficacy (SWE) 3. everyday competences (ECQ) 4. quality of life (WHO Wellbeing Five) 5. subjective wellbeing (SF-36) 6. social participation 7. physical activity MRT: 1. MP-RAGE-data set (volumetry, VBM) 2. DTI (TBSS-Analyse) 3. resting state fMRI 4. FLAIR (quantification of lesion volumina) Cortisol day profile (with dexamethason suppression test) All examinations will be performed before the intervention, after 6 months, and after 12 months. | — |
Countries
Germany
Contacts
Public ContactMartin Griebe
Neurologische KlinikUniversitätsmedizin MannheimUniversität Heidelberg
Outcome results
None listed