disinhibited eating behaviour E66
Conditions
Interventions
Group 1: Investigation of 40 non-smoking obese volunteers with BMI >35 kg/m2 of whom N=20 have high disinhibition and N=20 have low disinhibition regarding their eating behaviour with simultaneous PE
Sponsors
Universitätsklinikum Leipzig AöR
Klinik und Poliklinik für Nuklearmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - obese: BMI > 35 kg/m²; healthy control: BMI < 25 kg/m2 - age between 18-65 years; ? / ? - non-smoking
Exclusion criteria
Exclusion criteria: - current or past neurological or psychiatric disease, (i.e. depression and anxiety) - neurosurgical interventions - structural tissue lesions in the braín (e.g. stroke, trauma) - use of anorexic medication or other interventions for weight loss in the past 6 months - prescription medication (i.e. neurotropic drugs); - past or present history of alcohol misuse or the use of illegal drugs (ensured by means of psychological tests and urine Screening) - known cognitive deficits or speech impairment - simultaneous participation in any other interventional clinical study according to the German Medicinal Products Act (MPA) - pregnancy and breast-feeding (or other contraindications for the use of radiotracers) - MRI contraindications such as ferro-magnetism, or claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of our study is the quantitatively determined availavbility of the central a4ß2*-nAChR (binding potential and distribution volume ratio) in the human brain. | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI-(resting state; task-related fMRI data, especially markers of connectivity), behavioural (impulsivity, cognition, social development) as well as hormonal (leptin, ghrelin, insulin) Parameters and their correlation with a4ß2*-nAChR binding potential and distribution volume ratio. | — |
Countries
Germany
Contacts
Public ContactSwen Hesse
Univesitätsklinikum Leipzig Klinik und Poliklinik für Nuklearmedizin
Outcome results
None listed