Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00010907

Enrollment

Registered

2019-06-05

Start date

2017-05-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F90.0

Interventions

Group 1: 20 minutes of transcranial alternating current stimulation (individual stimulation frequency determined via time frequency analysis of P300 activity pre intervention, intensity of stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: •Age: 18-60 •Emmetropia •Right-handedness •German speaking •ADHD diagnosis based on DSM-V •Retrospektive perserverence of ADHD symptomatology into adulthood (Wender-Utah-Rating Scale: Retz-Junginger, Retz et al. 2002) •informed consent

Exclusion criteria

Exclusion criteria: •Magnetizable metal near brain/skull •Cochlea implants •Implanted neurostimulator •Epilepsiy (within previous medical history or family) •(comorbide) neurologic conditions •Severe affective disorders/schizophrenia/substance addiciton/autism •Dermatosis •Pregnancy •Medication had to be discontinued at least 3 days prior to the day of measurement •No other psychopharmacological medication

Design outcomes

Primary

Measure	Time frame
P300 amplitude was defined as the maximum value of the averaged ERP waveform in µV at Pz electrode per block and patient. P300 parameters were derived from pre and post block trials respectively. Indiviual change pre-to-post was then compared between the experimental groups. (2 x 2 design)	—

Secondary

Measure	Time frame
Response time in ms, defined as time between presentation and button press (instructed for oddball "X" stimuli), averaged over block and patient. 2 types of errors measured in absolute number: Miss when button was not pressed in time window between 200 and 1000ms after "X" presentation, False Alarm when button was pressed in response to "O" stimulus, averaged across block and patient. Group were then compared using individual differences between the block averages. (2 x 3 design)	—

Measure

Time frame

Response time in ms, defined as time between presentation and button press (instructed for oddball "X" stimuli), averaged over block and patient. 2 types of errors measured in absolute number: Miss when button was not pressed in time window between 200 and 1000ms after "X" presentation, False Alarm when button was pressed in response to "O" stimulus, averaged across block and patient. Group were then compared using individual differences between the block averages. (2 x 3 design)

—

Countries

Germany

Contacts

Public ContactChristoph Herrmann

Department of Psychology, European Medical SchoolCarl von Ossietzky Universität

christoph.herrmann@uni-oldenburg.de0441 798 4936

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026