G20
Conditions
Interventions
Group 1: Patients with Parkinson's Disease with STN-DBS
conduct of neuropsychological and clinical assessments
Group 2: Patients with Parkinson's Disease without STN-DBS
conduct of neuropsychological and clinical assessments
Group 3: Healthy participants (control group)
conduct of neuropsychological assessments
Sponsors
Medizinische Psychologie: Neuropsychologie und Gender Studies, Uniklinik Köln
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria patients with Parkinson's Disease with STN-DBS • Clinical diagnosis of idiopathic PD (UK Brain Bank criteria, Hughes et al., 1992) • Planned STN-DBS surgery • Patients up to 80 years of age • Minimum MMSE score = 25 • Able to give written informed consent • German as native language Inclusion criteria patients with Parkinson's Disease without STN-DBS • Clinical diagnosis of idiopathic PD (UK Brain Bank criteria, Hughes et al., 1992) • Patients up to 80 years of age • Minimum MMSE score = 25 • Able to give written informed consent • German as native language Inclusion criteria healthy controls • Individuals up to 80 years of age • Minimum MMSE score = 25 • Able to give written informed consent • German as native language
Exclusion criteria
Exclusion criteria: Exclusion criteria patients: • Any other neurological diseases besides PD (e.g., stroke, TBI, epilepsy) • Psychiatric diseases (e.g. schizophrenia, bipolar disorder) • Drug/medication addiction and/or alcohol addiction • Patients at a late stage of the disease (stage 4 H &Y) • Signs of dementia (MMSE < 25) • Patients who are under medication for another disease indication with possible effects on the CNS Exclusion criteria healthy controls: • Indviduals with a clinical diagnosis of idiopathic PD • Any other neurological or psychiatric disease • Individuals who are cognitively impaired (e.g., vascular incidents, dementia, etc.) • 1 week before the testing: intake of substances that impact on the CNS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Social maladaption, measured by: self estimation and risk-seeking behavior in a social context, Reading the Mind in the Eyes Test, Ultimatum Game, Emotional competence questionnaire, NEO-FFI, DASS, Mild Behavioral Checklist; conduct of all tests and questionnaires at all time points of measurement (pre-surgery, 3-months post-surgery and 12-months post-surgery) | — |
Secondary
| Measure | Time frame |
|---|---|
| General cognitive state: Mini Mental State Examination, PANDA, Dementia Rating Scale (Mattis) executive functions: Trail Making Test A/B, verbal fluency, modified Wisconsin Card Sortng Test, BADS (key search test), Stroop test, LPS-4 memory: CERAD subtest (word list immediate & delayed recall) attention: Brief Test of Attention visuo-constructive abilities: CERAD subtest (figure copying) Psychiatric symptoms: Beck-Depression Inventory, mania self-evaluation scale, apathy evaluation scale, QUIP-RS quality of life: PDQ-39 social desirability: SES; conduct of all tests and questionnaires at all time points of measurement (pre-surgery, 3-months post-surgery and 12-months post-surgery) | — |
Countries
Germany
Contacts
Public ContactAlexandra Zapf
Uniklinik KölnMedizinische Psychologie
Outcome results
None listed