N18.5
Conditions
Interventions
Group 1: Low-flux hemodialysis over four to five hours three times weekly for six weeks
Group 2: High-flux hemodialysis over four to five hours three times weekly for six weeks
Group 3: High efficienc
Sponsors
Dialysezentrum Elsenfeld
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: •Age = 18 years •End-stage renal failure •Chronic hemodialysis or hemodiafiltration treatment for more than three months •Hematocrit above 30 % •Stable anticoagulation and erythropoietin regimen •No vascular access related problems (A/V-fistula or bi-flow catheter) •No ongoing infection •Signed informed consent form
Exclusion criteria
Exclusion criteria: •Inclusion criteria not met •Known HIV or hepatitis B or C infection. •Pregnancy •Unstable clinical condition (e.g. cardiac or vascular instability) •Life expectancy less than 12 months •Known coagulation problems •Patients participating in another study interfering with the planned trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of posttranslationally modified proteins | — |
Secondary
| Measure | Time frame |
|---|---|
| •Dialysis dose Kt/V •Urea serum levels •Protein catabolic rate •Serum amino acids in blood and dialysate •Small and middle molecular toxin removal •Serum levels of protein-bound uremic toxins •C-reactive protein | — |
Countries
Germany
Contacts
Public ContactDetlef Krieter
Dialysezentrum Elsenfeld
Outcome results
None listed