healthy, female participants
Conditions
Interventions
Group 1: repeated oral administration of hydrocortisone (20mg) on ??three consecutive days, starting one day after the induction of an analog trauma using the Trauma-film paradigm (presentation of ave
Sponsors
Universität des Saarlandes, Klinische Psychologie und Psychotherapie
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: healthy, female participants, taking hormonol contrazeptives, non-smokers and normal weight
Exclusion criteria
Exclusion criteria: - acute or chronic somatic or psychiatric disorders - current or previous increase of intraocular pressure (glaucoma) - positive family history of cerebral seizures or arterial vascular anomalies (aneurysms) - vaccination in the last 2 months or (planned) in the following month - participation in pharmacological studies within the last 2 months - an increased arterial blood pressure (greater than 140/90 mmHg) - pregnancy or lactation - - taking medication (except occasionally aspirin or acetaminophen to no more than one week prior to study entry) - body mass index under 19 and over 26 - regular use of nicotine, alcohol or drugs - previous traumatic experiences - previous or acute depressive moods
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of: - Intrusionfrequency and -distress with an electronic diary (iPod) over the duration of the experiment (4 days) beginning immediately after the presentation of the trauma-film - excplicit memory on the film content with a specially designed memory task three days after film presentation (true / false judgments regarding statements on the content of the trauma film), - basal cortisol levels 1 week prior the study - cortisol levels (cortisol awakening response and reactivity of cortisol administration) on the test days as well as between the days of testing, - continuous physiological parameters such as ECG, EDA and blood pressure on both days of testing - subjective ratings regarding the anxiety and stress with the STAI and the PANAS | — |
Secondary
| Measure | Time frame |
|---|---|
| predisposing factors: conditionability, stress reactivity, personality factors, peripheral physiological parameters (f.e. heart rate variability), basal cortisol levels | — |
Countries
Germany
Contacts
Public ContactAlexandra-Heike Gräbener
Universität des Saarlandes, Klinische Psychologie und Psychotherapie
Outcome results
None listed