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Effect of spinal cord and peripheral nerve stimulation on sensory profile and on endogenous pain modulation

Effect of spinal cord and peripheral nerve stimulation on sensory profile and on endogenous pain modulation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00010607
Enrollment
28
Registered
2016-09-28
Start date
2014-09-22
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

complex regional pain syndrome, peripheral nerve injury, raduculopathy, polyneuropathy M89.0 G56.4 M54.1 G62.9 G56 G57 G58

Interventions

Group 1: Quantitative Sensory Testing (QST, DFNS protocol), conditioned pain modulation (CPM) and skin temperature measurement in the affected area and contralateral were examined. First measurement a

Sponsors

Abteilung für Schmerzmedizin,Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusuion criteria was a reported beneficial effect to neurostimulation and the ability to understand the study design.

Exclusion criteria

Exclusion criteria: Exclusion criteria were no pain relief after SCS or PNS implantation, pain duo to angina pectoris and stump pain after amputation, mental limitations and spasm following neurostimulation.

Design outcomes

Primary

MeasureTime frame
Quantitative Sensory Testing (QST, DFNS protocol), conditioned pain modulation (CPM) and skin temperature measurement in the affected area and contralateral were examined at first with inactivated stimulation and then with activated stimulation. QST investigates the function of thick-, thinly- and unmyelinated nerve fibers (A-ß, A-d and C nerve fibers). CPM evaluates the efficacy of diffuse noxious inhibitory controls (DNIC). Temperature measurement is an established indirect technique to detect sympathetic blockade, shown through an increase of skin temperature.

Secondary

MeasureTime frame
Correlation between this changes and the analgesic effect was assumed.

Countries

Germany

Contacts

Public ContactChristoph Maier

Abteilung für Schmerzmedizin,Berufsgenossenschaftliches UniversitätsklinikumBergmannsheil

christoph.maier@ruhr-uni-bochum.de0049234-302-6366

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026