In the first phase of the study, only healthy subjects are examined.Future studies with patients suffering from anxiety disorders and PTSD might be considered.
Conditions
Interventions
Group 1: Intranasal insulin (160 IU, single dose)
Group 2: Intranasal Placebo (diluting medium for insulin, single dose)
Sponsors
Universität des SaarlandesKlinische Psychologie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: - Healthy participants between 18 and 45 years old - Normal weight - For women: regular intake of contraceptives
Exclusion criteria
Exclusion criteria: - Acute or chronic medical/psychiatric problems - Intake of medication (exception: contraceptives; ocassional Aspirin or Paracetamol, last time maximum one week before beginning of the study) - Participation in pharmacological studies in the last 4 weeks - Regular consum of nicotine, alcohol or drugs - Previous traumatic experience or acute depressive feelings - Pregnancy or nursing period - Tinnitus - Diabetes (also from parents and siblings) - Diseases and anatomic deviations of the nose
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| - Heart rate variability (HRV) and electrodermal response (EDA) assessed during resting state at different points of the experiment - Questionnaires and tests (BDI, STAI-T, SCI, BFI-S, VVM) assessed before the first experimental phase - Questionnaires and subjective ratings (STAI-S, arousal, stress, activation, anxiety and unpleasantness of electroshock) assessed throughout the experiment - Basal cortisol measured on the day of insulin/placebo administration (CAR, Cortisol awakening response) and cortisol levels measured throughout the experiment. - Blood glucose after intranasal insulin/placebo application measured with a blood glucose-monitoring device. | — |
Primary
| Measure | Time frame |
|---|---|
| - Differences in fear extinction and reinstatement between groups (intranasal insulin vs. intranasal placebo) - Paradigm: Differential Fear Conditioning - Measures of interest: Electrodermal response (EDA), startle reaction (EMG of the orbicularis oculi muscle), heart rate (ECG), subjective ratings of the stimulus (contingency awareness, valence, expectancy) measured throughout the experiment. | — |
Countries
Germany
Contacts
Public ContactDiana Ferreira de Sá
Universität des SaarlandesKlinische Psychologie und Psychotherapie
Outcome results
None listed