Patients (> 18yrs) who undergo general anesthesia for an elective procedure (ENT surgery, ophthalmic surgery and dermatologic surgery).
Conditions
Interventions
Group 1: Patients who are administered propofol by weight (2mg/kg Propofol) for induction of anesthesia
Group 2: Patients who were administered propofol for induction of anesthesia guided by BIS (targ
Sponsors
Uniklinikum Gießen und Marburg, Standort Marburg, Klinik für Anästhesie und Intensivtherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Eligible participants were patients aged 18 or over scheduled to undergo elective surgery (ear nose and throat (ENT) surgery, ophthalmic surgery and dermatologic surgery) under general anaesthesia.
Exclusion criteria
Exclusion criteria: Exclusion criteria were participation in another study, pregnancy and lactation, any medical condition that would require rapid sequence induction, ASA physical status > 3, any disease with a potential for compromised alertness (due to underlying disease or sedative premedication).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of this study is the number (proportion) of patients with hypotension. Blood pressure was measured every 2 minutes during the study period (the first 12 minutes after the start of induction of anaesthesia). We defined hypotension as mean arterial pressure (MAP) < 60 mmHg in accordance with the most common definitions used to study intraoperative hypotension. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are: - the degree of hypotension (defined as the difference between baseline MAP and MAP at the subsequent measurements (? MAP)); - the degree of maximal hypotension (defined as the maximal difference between baseline MAP and lowest MAP (? MAP) at any of the subsequent measurments); - the ratio of hypotensive vs. normotensive MAP measurements; - the correlation between BIS-index and MAP; - the number (proportion) of patients administered vasopressors and number (proportion) of patients in whom Trendelenburg-positioning was performed at the discretion of the anaesthetist to treat a drop in blood pressure; - the number (proportion) of patients with bradycardia (heart rate 100 / min); - the number (proportion) of patients with hypertension (MAP > 140 mmHg). | — |
Countries
Germany
Contacts
Public ContactHinnerk Wulf
Uniklinikum Gießen und Marburg, Standort Marburg, Klinik für Anästhesie und Intensivtherapie
Outcome results
None listed