Effect of garlic extract on selected biochemical parameters in obese patients with hypertension. E66
Conditions
Interventions
Group 1: Study group - 400mg of garlic extract (capsules) /day, duration of treatment - 3 months
Group 2: Placebo group - 400mg/d placebo (pure midrocrystalline cellulose) for 3 months
Sponsors
Department of Education and Obesity Treatment and Metabolic Disorders
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were a body mass index (BMI) equal to or greater than 30 kg/m2, age 25 to 60 years, stable body weight (< 3 kg self-reported change during the previous three months), and no drug- treated hypertension (meaning systolic blood pressure (SBP) less than 160 mmHg and diastolic blood pressure (DBP) less than 100 mmHg) with stable treatment for at least 6 months (diet, physical activity, life style). The treatment scheme was comparable for both the placebo and the garlic group.
Exclusion criteria
Exclusion criteria: The exclusion criteria were secondary obesity or secondary hypertension; diabetes; a history of coronary artery disease, stroke, congestive heart failure, or malignancy; a history of use of any dietary supplements within the three months prior to the study; a current need for modification of antihypertensive therapy; abnormal liver or kidney function; any clinically significant process; a history of infection in the month prior to the study; nicotine or alcohol abuse; or other condition that, in the opinion of the investigators, would make participation not in the best interest of the patient or could prevent, limit, or confound the protocol-specified efficacy assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The values of inflammation markers and PAI-1 level before and after 3 months of suplementation of Garlic extract | — |
Secondary
| Measure | Time frame |
|---|---|
| The values of blood pressure before and after 3 months of suplementation of Garlic extract. The values of stiffnes index before and after 3 months of suplementation of Garlic extract The levels of lipid parameters before and after 3 months of suplementation of Garlic extract | — |
Countries
Poland
Contacts
Public ContactPawel Bogdanski
Department of Education and Obesity Treatment and Metabolic Disorders
Outcome results
None listed