J30.3 J45.0
Conditions
Interventions
Group 1: Patients with a positive skin prick test after bronchial allergen challenge will be asked to participate in the study. Within 12 weeks, the patient will be reinvited for the second visit. The
Sponsors
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main
Eligibility
Sex/Gender
All
Age
5 Years to 24 Years
Inclusion criteria
Inclusion criteria: Diagnosis of mite allergy (skin prick test = 3mm) Known asthma and / or allergic rhinoconjunctivitis Bronchial allergen challenge performed in the preceding 12 weeks exacerbation free interval> 4 weeks before visit 1 Written informed consent of the parents and the child / adolescent
Exclusion criteria
Exclusion criteria: Age 25 years Exacerbation of asthma within the last 28 days Severe symptoms of allergic rhinitis or relevant deterioration of allergic symptoms Intake of the following drugs before testing: Decongestant nose drops one day, antihistamines three days, nasal steroids 14 days, oral cortisone four weeks, leukotriene antagonists and cromoglycic acid three days before nasal provocation challenge. Adenoids or nasal surgery in the last three months Serious deviation of the nasal septum Other serious diseases (for example, cystic fibrosis, diseases with immunosuppression, malignancies) Pregnancy, lactation Participation in another clinical trial <30 days Inability to understand the scope of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Primary endpoint is the concordance of the nasal and bronchial allergen challenge for the grading negative, moderate and severe allergic reaction | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of peak nasal inspiratory flow and nasal symptoms to the lokal and serum IgE. Comparison of the IgE repertoire (epitope spectrum) nasal vs. serum IgE. | — |
Countries
Germany
Contacts
Public ContactAnna Buslau
Klinik für Kinder- und Jugendmedizin
Outcome results
None listed