Healthy Subjects L29.8
Conditions
Interventions
Group 1: Healthy controls:
Per age group (20-40 years old, 40-60 years old, 60-80 years old) and gender (male and female) 20 healthy controls (n= 120 healthy controls) a skin biopsy will be taken and
Sponsors
Kompetenzzentrum chronischer Pruritus (KCP) und Klinik für Hautkrankheiten Universitätsklinikum Münster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Subproject 1: Gender: Both, male and female Minimum age:18 years old Age limit:No age limit Subproject 2: Gender: Both, male and female Minimum age:18 years old Age limit:No age limit Presence of atopic dermatitis or neuropathic pruritus on one of the following localizations: - Lower leg 10cm above the malleolus lateralis - Forearm centered above the musculus brachioradialis - Shoulder blade
Exclusion criteria
Exclusion criteria: Subproject 1: Presence of pruritus or skin disease of any kind History of atopic disposition History of diabetes mellitus type I or II History of hepatitis B/C or HIV infection Existing neurological or psychiatric disease Allergy to local anesthesia, adhesive bandages or latex Continuous use of the following medications: antidepressants, anticonvulsives, antipsychotics Long-term use of analgesics Pregnancy (inquire about oral contraception, last menstrual cycle), breast feeding Lack of understanding of the language, reading difficulties/visual impairment Subproject 2: History of diabetes mellitus type I or II History of hepatitis B/C or HIV infection Existing neurological or psychiatric disease Allergy to local anesthesia, adhesive bandages or latex Continuous use of the following medications: Antidepressants, anticonvulsives, antipsychotics Long-term use of analgesics Pregnancy (inquire about oral contraception, last menstrual cycle), breast feeding Lack of understanding of the language, reading difficulties/visual impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the variation of intraepidermal nerve fiber density (IEFND) and intraepidermal and dermal nerve fiber anatomy (NFA) on different skin localizations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in the variation of the IEFND and NFA in men and women Difference in the variation of the IEFND and NFA in different age groups Difference in the variation of the IEFND and NFA in different itchy diseases (atopic eczema, neuropathic pruritus) | — |
Countries
Germany
Contacts
Public ContactSebastian Mühl
Klinik für Hautkrankheiten, Universitätsklinikum Münster
Outcome results
None listed