C71
Conditions
Interventions
Group 1: MRI examinations with a special sequence for the representation of the hippocampus, time points as in the clinical routine.
Neuropsychological tests before radiotherapy and 3 months, 6 months
Sponsors
Universitätsklinikum Dresden, Klinik für Strahlentherapie und Radioonkologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Supratentorial gliomas grade III (anaplastic glioma) - Glioblastoma, when the patient can be assigned to EORTC RPA Class III or IV - ECOG = 2 - Indication for high-dose radiotherapy or radiochemotherapy - Capacity to consent and written consent of the patient - German is the dominant language, if multilingualism is present
Exclusion criteria
Exclusion criteria: - Patients with median survival 50 years old AND only biopsy, no extirpation AND slightly or severely limited cognitive performance) - Limitation of the expected survival time of <12 months due to other diseases - Tumors of other histology or location - Pre-irradiation of the brain - Tumor recurrence - Lack of capacity to consent or lack of written consent of the patient - Inability to MRI planning (eg. contraindications to performing MRI) - Lack of compliance of the patient - Lack of or limited possibility of a reproducible storage (eg by severe restriction of mobility of the patient)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volumetry of the hippocampus (MRT) in correlation with the neuropsychological performance after 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Local tumor control rate and acute and late toxicity > grade II after 2 years, analysis using Kaplan-Meier plots Correlation with other MR parameters (e.g. Cortex-thickness hippocampal subregions) after 6 months | — |
Countries
Germany
Contacts
Public ContactAnnett Klöber
Universitätsklinikum Dresden, Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Klinisches Studienzentrum
Outcome results
None listed