silent cerebral lesions Impairment of cognitive performance after VOV
Conditions
Interventions
Group 1: MRI of the head as well as the implementation of the MoCA test before and after the VOV- intervention had taken place, follow-up after 2 weeks, clinical follow-up after three months. The firs
Sponsors
Charite Berlin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: There are both women (after exclusion of pregnancy), and men who are over 18 years old, included with atrial fibrillation and atrial appendage closure planned. There must be no contraindications for MRI. Consent for study participation.
Exclusion criteria
Exclusion criteria: Pregnancy. Neurological event within 3 months prior to the atrial appendage closure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of silent cerebral lesions on MRI of the head before and after atrial appendage closure (VOV). The first MRI is performed immediately prior to VOV. The second cerebral MRI within 48h after VOV. The primary endpoint is reached when new cerebral lesions are visible on MRI after VOV. | — |
Secondary
| Measure | Time frame |
|---|---|
| Impairment of cognitive performance with neurocognitive questionnaire (MOCA) test before and after left atrial appendage occlusion. The secondary endpoint is achieved when there is a deterioration of MOCA test. The first MOCA test is performed immediately prior to VOV. The Second within 48h after VOV. | — |
Countries
Germany
Contacts
Public ContactBarbara Bellmann
Charite Berlin Abteilung für Kardiologie Campus Benjamin Franklin
Outcome results
None listed