Isolation of hematopoietic stem cells from placenta and cord blood to generate a humanized mouse model

Isolation of hematopoietic stem cells from placenta and cord blood to generate a humanized mouse model - IsoNaP

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00010283

Enrollment

300

Registered

2016-08-09

Start date

2016-09-26

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

placenta, umbilical cord

Interventions

Group 1: Isolation of hematopoietic stem cells (CD34+, CD45dim) from umbilical cord blood and plazenta tissue are performed by flushing/perfusion or by the use of enzymatic digestion. Subsequently ce

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: written informed consent

Exclusion criteria

Exclusion criteria: diseases of the hematopoietic system; infectious diseases

Design outcomes

Primary

Measure	Time frame
Isolation of hematopoietic stem cells	—

Secondary

Measure	Time frame
Reconstitution of humanized immune system in mice	—

Countries

Germany

Contacts

Public ContactFlorian Klein

Labor für experimentelle ImmunologieKlinik I für Innere Medizin, Zentrum für Molekulare Medizin

florian.klein@uk-koeln.de+49 221 478 89693

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026