Realtime fMRI Neurofeedback in the Treatment of Alcohol Use Disorder

Realtime fMRI Neurofeedback in the Treatment of Alcohol Use Disorder - SyBil-AA Neurofeedback

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00010253

Enrollment

100

Registered

2016-05-10

Start date

2016-03-30

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F10.2

Interventions

Group 1: fMRI neurofeedback control region upregulation while presenting alcohol cues (images of the favorite beverages) to the patients, 3 sessions à ca. 30 min within a maximum of two weeks. Group 2

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: -Gender: Both, male and female -Age: 18 and 65 years -Normal or corrected to normal vision with best corrected visual acuity ( > 0,8, Landolt C rings) -appropriate comprehension of the German language -written informed consent -Alcohol use disorder according to DSM-IV and ICD-10 -abstinent for 5-28 days at first assessment, finished alcohol detoxification

Exclusion criteria

Exclusion criteria: -Axis I mental disorders (SCID-I) during the last 12 months except (for patients) abuse and dependence of alcohol and nicotine -neurological disorders -epilepsy -exclusion criteria for MRT (pace maker, implanted metal or pregnancy) -positive drug screening -any current psychoactive medication for the last 3 days before study entry -suicidal tendencies

Design outcomes

Primary

Measure	Time frame
Rate of relapse after neurofeedback training: - follow-up contacts after 1, 2 (phone interview) and 3 months (interview in the clinic) after the completion of neurofeedback Training. -Form 90 (Structured Assessment Interview for Drinking and Related Behaviors) - OCDS-G (Obsessive compulsive Drinking Scale) - CAS-A (Craving-Automatized-Scale-Alcohol) - AASE(Alcohol Abstinence Self-Efficacy Scale) - AUQ (Alcohol Urge Questionnaire) -breath test and blood test (at the beginning of the interview in den clinic, after 3 months of the last neurofeedback training)	—

Measure

Time frame

Rate of relapse after neurofeedback training: - follow-up contacts after 1, 2 (phone interview) and 3 months (interview in the clinic) after the completion of neurofeedback Training. -Form 90 (Structured Assessment Interview for Drinking and Related Behaviors) - OCDS-G (Obsessive compulsive Drinking Scale) - CAS-A (Craving-Automatized-Scale-Alcohol) - AASE(Alcohol Abstinence Self-Efficacy Scale) - AUQ (Alcohol Urge Questionnaire) -breath test and blood test (at the beginning of the interview in den clinic, after 3 months of the last neurofeedback training)

—

Secondary

Measure	Time frame
Functional changes (activation and connectivity) in the brain over the sessions assessed with magnetic resonance Imaging. Changes in alcohol craving during the sessions assessed by a visual analogue scale. Predicitive power of magnetic resonance Imaging for learning neurofeedback and for the success of the intervention. Differences in effectivity of the group-specific interventions.	—

Countries

Germany

Contacts

Public ContactNathalie Bahs

Zentralinstitut für Seelische Gesundheit

nathalie.bahs@zi-mannheim.de062117033723

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 24, 2026