Comorbid alcohol dependence and depression F10 F33
Conditions
Interventions
Group 1: Cormorbid patients receiving Behavioral Activation Training
Workpackage 1: All participants will receive a baseline fMRI session, as well as questionnaires.
Workpackage 2: Behavioral Activa
and (d) monitor, support, and reward achieving
behavioral goals. Previous studies have demonstrated that BAT for depression effectively reduces
depressive symptoms and is well tolerated in outpatient
Sponsors
Abteilung Klinische Psychologie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim/ Universität Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with alcohol abuse diagnosed according to DSM-5 criteria 2. Patients with depression diagnosed according to DSM-5 criteria 3.Patients with comorbid alcohol abuse and depression diagnosed according to DSM-5 criteria 4. Healthy controls as confirmed by SCID Interview
Exclusion criteria
Exclusion criteria: Exclusion criteria include psychiatric Axis I disorders (as measured by the SCID I interview) except for patients alcohol and nicotine abuse and depressive symptoms, neurological disorders, MRI specific criteria (pace maker or implanted metal), positive drug screening, at least 3 days without psychoactive medication before the first measurement, pregnancy and suicidal tendencies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neural correlates of reward and emotion processing in patients and healthy controls will be assessed at two time points by means of fMRI. While the first measurement (at baseline) will identify common and/or distinct neural signatures underlying the comorbidity of alcohol dependence and depression, the second measurement (after 6 weeks training) allows investigating the influence of the psychotherapeutic interventions on these target brain mechanisms. Consequently, in this study neural activation and connectivity in the reward system and default mode network are the primary outcome measures. | — |
Secondary
| Measure | Time frame |
|---|---|
| The questionnaire data is collected for all subjects before the first fMRI measurement. For the comorbid patients, the same data is recorded in addition to the second fMRI measurement and 3 months later. Sociodemographic data, information about course of disease and current and previous treatment • Structured interview External assessment of psychopathology • Structured Clinical Interview for DSM-ICD, SCID-I (First et al., 1998) Self- and external assessment of depression • Beck Depression Inventar (BDI-II) • Montgomery and Asperg Depression Rating Scale (MADRS) Self- and external assessment of alcohol use and craving • Form 90 Interview • Obsessive Compulsive Drinking Scale • Alcohol Urge Questionnaire • Alcohol Dependence Scale Habitual Rumination • Response-Styles-Questionnaire (RSQ-D) • Perseverative Thinking Questionnaire Mindfulness • Mindfulness Attention and Awareness Scale (MAAS) Self-confidence •Rosenberg Selbstwert Skala •Skala zur Erfassung der Selbstakzeptierung •Forms of Self-Criticising/Attacking and Self-Reassuring Scale Quality of life Lebensqualität • Münchner Lebensqualitäts-Dimensionen Liste (MLDL) | — |
Countries
Germany
Contacts
Public ContactAlena Becker
Aabteilung Klinische Psychologie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim/ Universität Heidelberg
Outcome results
None listed