Patients from other diagnosis groups if they are referred to our memory clinic with cognitive disturbances for diagnostic assessment (e.g. patients with depression in old age according to ICD-10 F32/33). F00 F01 F02 F06 F07
Conditions
Interventions
Group 1: Patients who refer to our memory clinic undergo a comprehensive diagnostic examination according to the S3 guidelines on dementia. In each case, a neuropsychological evaluation with the Mini-
Sponsors
Ärztlicher Direktor, Vitos Klinikum Gießen-Marburg
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: For the prospective study part: Treatment at the Vitos Clinic for Psychiatry and Psychotherapy Gießen and Marburg (Vitos Clinical Centre Giessen-Marburg) as inpatient, partial inpateint or outpatient, age > 50 years, ability to consent at the initial examination, indication for diagnostic examination,referral by a medical specialist. For the retrospective study part: referral of a patient to memory clinic by a medical specialist in the time between August 2013 and June 2015.
Exclusion criteria
Exclusion criteria: For the prospective study part: lack of ability to consent at the initial examination, diagnosed dementia with a duration of > 2 years. For the retrospective study part: no exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Longitudinal deterioration of cognition as assessed by changes of the Clinical Dementia Rating Scale (= 0,5 points) from the first time of measurement (initial examination in our memory clinic) to the follow up assessments after 6, 12, 18 and 24 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Subjective cognitive complaints (questionnaire with 6 items), 2. stress processing (Stressverarbeitungsfragebogen, SVF-20), 3. anxiety and depressivity by the Hospital Anxiety and Depression Scale (HADS) and Geriatric Depression Scale (GDS), the latter performed as an interview, 4. positive future or life orientation by the short version of the Sense of Coherence Scale (SOC, 3 Items), 5. sleep quality and circadian preference (chronotype) by the Pittsburgh Sleep Quality Index (PSQI) and a short Version of the Morningness-Eveningness-Questionnaire (rMEQ), 6. standardized testing of mobility ("timed up-and-go test"), 7. olfactory perception by semiquantitative olfactometry, 8. actigraphically evaluated sleep for one night, 9. biological stress reactivity (cortisol and alpha-amylase in saliva with sampling at fixed times: before and during the neuropsychological examination as well as on the subsequent day before and during other diagnostic procedures), 10. screening of restless legs syndrome (Restless Legs Syndrome Diagnosis-Index), 11. vascular risk factors (Hachinski Scale), 12. neuropsychological Parameters (MMSE and CERAD-Plus), 13. diagnostic structural brain imaging (qualitative findings, visual score for white matter lesions), 14. cerebrospinal fluid biomarkers (Aß1-42, p181Tau and total Tau) obtained by lumbar puncture. The variables mentioned under point 1-12 are assessed at each time of measurement (i.e. initial examination in our memory clinic as well as after 6, 12, 18 and 24 months). Structural brain imaging and lumpar puncture is in each case performed at the initial examination, the latter is repeated after 12 months. | — |
Countries
Germany
Contacts
Public ContactChrista Speier
Vitos Klinik für Psychiatrie und Psychotherapie Gießen
Outcome results
None listed