sleep deprivation healthy participants
Conditions
Interventions
Group 1: The participants stay in the sleep laboratory for 11 nights: one adaptation night (8 h sleep) followed by two baseline nights (8 h sleep), five nights of chronic sleep deprivation (5 h sleep)
Sponsors
Deutsches Zentrum für Luft- und Raumfahrt, Institut für Luft- und Raumfahrtmedizin, Abteilung für Flugphysiologie
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Age between 20 and 40 years; men or women; presence of a written informed consent; women in a reproductive age a negative pregnancy test and an effective contraception for at least 3 months
Exclusion criteria
Exclusion criteria: BMI > 30; missing of a legally effective informed consent; not able to speak German; medication which influences research parameters; blood-thinning medication or known coagulation disorder; chronic diseases; sleep disturbances; shift or night work; cumulative or professional radiation exposure; treatment/experiment with radioactive substances or radiation exposure during the last 10 years; drug dependence, smokers; electric implants for stimulation or therapy; metallic objects in or on the body (e.g. surgical screws) without MRI-compatibility; fixed braces or retainer; tattoos in the region under investigation; intense grinding operations on metallic objects in the month ago; disturbances, e.g. back pain, which complicate lying still; pregnancy, breast feeding; people not qualified for legal acts or in custody; every other condition which, according to the medical doctors involved, makes someone unsuited for participating in the study, copper spiral, contraceptive coil interacting with MRT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PET is measured during the fifth day of chronic sleep deprivation, after the following recovery night and during the acute sleep deprivation day to capture changes in adenosine receptor density. | — |
Secondary
| Measure | Time frame |
|---|---|
| High-density wake-eeg and pupillography are measured in the mornings from the second baseline day on until (including) the day of acute sleep deprivation. These measurements capture changes in the brain's electrical activity and pupils. A cognitive test battery (performance tests and questionnaires about sleepiness and mood) takes place every 3 hours during wakefulness to capture variations. Eyelid velocity is measured during the second baseline day, the fifth day of chronic sleep deprivation and the following two days all day long. A test of metabolic control is performed during the same days. | — |
Countries
Germany
Contacts
Public ContactEva-Maria Elmenhorst
Deutsches Zentrum für Luft- und Raumfahrt, Institut für Luft- und Raumfahrtmedizin, Abteilung für Flugphysiologie
Outcome results
None listed