G20 F06.7
Conditions
Interventions
Group 1: Cognitive training
Group 2: Physical training
Sponsors
Medizinische Psychologie Uniklinik Köln
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: • PD according to United Kingdom Brain Bank Criteria • PD-MCI according to international research criteria (Litvan, Goldman et al. 2012) • Disease duration = 3 years • Stable medication 4 weeks prior to pretest • Written informed consent
Exclusion criteria
Exclusion criteria: • Severe comorbidity with influence on medication or life expectancy or quality of life during the study (i.e. malignant disease with life expectancy < 6 months) • Depression (BDI-II, exclusion beginning with moderate symptoms: cut off =20) • Acute suicidality, ascertained anamnestically • Marked daytime sleepiness, ascertained anamnestically • Impuls controll disorder or dopamine dysregulation syndrom, ascertained anamnestically • Acute psychosis (or psychotic episode 6 months prior to study inclusion) • Acute medication with cholinesterase inhibitors or memantine • Participation in another medication or training study within 2 months prior to study inclusion • Deep brain stimualtion • Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -California Verbal Learning Test -Regensburger Verbal Fluency Test -Modified Wisconsin Card Sorting Test/Tower of London Test -Key Search Subtests -Rey-Oesterrith Complex Figure Delayed Recall -Backward Digit Span | — |
Secondary
| Measure | Time frame |
|---|---|
| -Benton Line Orientation Test -D2 Test of Attention & Endurance -Wechsler Intelligence Scale for Adults (Letter-Number Sequencing) -Boston Naming Test from the CERAD -Speech Comprehension from the Aphasie Checkliste -Rey-Oesterrith Complex Figure Copy -Bayer ADL Scale -PDQ-39 -Beck Depression Inventory II -FEDA Questionnaire of Self-Perceived Deficits in Attention | — |
Countries
Germany
Contacts
Public ContactInga Liepelt-Scarfone
Deutsches Zentrum für Neurodegenerative Erkrankungen und Hertie-Institut für Klinische HirnforschungUniversität Tübingen
Outcome results
None listed