Depression, Schizophrenia, borderline personality disorder F32 F33 F34.1 F43.2 F20-F29 F60.31
Conditions
Interventions
Group 1: Patients with a depressive disorder (ICD-10: F32, F33, F34.1 and F43.2) undergo different examinations during an observation period of 10 days: 1. Self rating scales for assessing mood, sleep
Sponsors
Vitos-Klinikum Gießen-MarburgÄrztlicher Direktor
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Outpatients, inpatients or day hospital patients with one of the following mental disorders: A) depressive disorder: Depressive episode (ICD-10: F32), recurrent depressive disorder (ICD-10: F33), dysthymia (ICD-10: F34.1), adjustment disorder with depressed mood (ICD-10: F43.2) or B) Schizophrenic disorder according to ICD-10 F2 or C) emotionally instable personality disorder (ICD-10: F60.3). D) Healthy subjects without current or past mental disorders (excepting ICD-10: F17). Further criteria: E) unmedicated or stable on psychotropic medication for at least 5 days, F) consent capacity and voluntary treatment and G) no other relevant physical illness or drug use.
Exclusion criteria
Exclusion criteria: For the patient groups: A) Mental disorders of the ICD-10 groups F0, F1 (except F17), F5-F7. B) Endocrine diseases (especially of the adrenal Cortex, thyroid hyper- or hypofunction), C) Neurological diseases with severe somatosensory deficits, D) Organic sleep disoders, E) Current or recent (3 months at maximum) treatment with steroids (except contraceptives), F) Pregnancy, G) Recent (within the last four weeks) disruptions of sleep-wake rhythmicity due to exogenous conditions such as shift work or travel across time zones with jet lag. For healthy controls: a current or past mental disorder (except ICD-10: F17) as well as the criteria B to G as described above for the patient groups
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Actigraphically measured sleep parameters, rest-activity rhythmicity (ratio between activity and inactivity state, the so-called relative amplitude), and measures of pain processing (pain complaints, pain sensitivity) in the course of 10 days. Measures of pain processing: quality and intensity of pain complaints on each evening and morning by a questionnaire (short version of the McQuill Pain Questionnaire, MPQ); Measures of pain sensitivity: pressure pain thresholds on each second evening and the following morning (i.e. five evening-morning sequences); thermal pain thresholds from day 2 (evening) to day 3 (morning) and from day 7 (evening) to day 8 (morning). | — |
Secondary
| Measure | Time frame |
|---|---|
| Measures of current mood states (Mood checklist based on categories and adjectives, BSKE), circadian and stress-related measures of the hypothalamic-pituitary-adrenal (HPA) axis activity and the sympathetic nervous system (cortisol, alpha-amylase): saliva samples (Salivette) on each second evening (one sample) and subsequent morning (four times within 60 minutes), daily stress ratings by a diary, personality traits such as neuroticism and chronotype by questionnaires (NEO Five-Factor Inventory, NEO-FFI; Morningness-Eveningness questionnaire, MEQ) at day 0 (baseline), neuropsychological parameters of cognitive speed and flexibility by the Trial Making Test (TMT-A and TMT-B) on the evening on day 1 and the morning on day 2. | — |
Countries
Germany
Contacts
Public ContactBernd Kundermann
Vitos Klinik für Psychiatrie und Psychotherapie Gießen
Outcome results
None listed