Determination of the bioavailability of folates

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00010137

Enrollment

Registered

2018-06-27

Start date

2016-03-17

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

Group 1: Control: 600 g of a water-pectin-sugar mixture Group 2: 600 g blended strawberries Group 3: 400 µg 5-CH3-H4 folate supplement served with 600 g of a water-pectin-sugar mixture

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: healthy volunteers, 18 up to 30 years of age, BMI<30 kg/m2, non-smoker, written informed consent

Exclusion criteria

Exclusion criteria: -BMI>30 kg/m2 -smoker -diseases affecting digetsion, resorption, and metabolism -type TT of the methylentetrahydrofolate reductase (MTHFR) gene -chronic diseases -acute infektion -pregnant and lactating women -known allergies or intolerances against tested food

Design outcomes

Primary

Measure	Time frame
Measurement of folate vitamers in plasma after ingestion of strawberries or folate supplement or control using HPLC-DAD and LC/MS-MS. Blood samples are taken 2 hours before the testmeal. 0min, 15min,30min, 45min, 60min, 75min, 90min, 105min, 120min, 3h, 4h, 5h, 6h, 7h, 8h, 9h, and 10h after the testmeal.	—

Countries

Germany

Contacts

Public ContactMichael Rychlik

Lehrstuhl für Analytische Lebensmittelchemie (ALMC)

michael.rychlik@tum.de08161-713153

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026