Influence of epigenetic factors of stress regulation
Conditions
Interventions
Group 1: a. Intervention stress through standardized
- Trier Social Stress Test ( TSST )
b . miRNAs / alpha-amylase ( AA ) / cortisol ( C )
During the intervention decrease / measurement at defined ti
Sponsors
Lehrstuhl für Medizintheorie, Integrative und Anthroposophische Medizin, Institut für Integrative Medizin, Universität Witten Herdecke
Eligibility
Sex/Gender
All
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: - written informed consent - females in second half of menstrual cycle
Exclusion criteria
Exclusion criteria: - emotional instability - necessitating treatment (i.e. pharmacological or non-pharmacological psychological treatment) - substance abuse or addiction - smoking - more than 3 cups of coffee or energy drinks regulary - females using hormonal contraceptives - pregnancy - ongoing breastfeeding - stress-relaxation exercises - cardiovaskular diseases - skin allergy against adhesive tapes or latex products
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Can stress-related miRNAs identified in saliva exosomes (at defined times during Trier Social Stress Test (TSST)) be significantly altered in response to an acute standardized social stress exposure? | — |
Secondary
| Measure | Time frame |
|---|---|
| Do responding miRNAs correlated with stress-associated salivary alpha-Amylase or Cortisol? Do responding miRNAs correlate with stress-associated modifications of heart rate and heart rate variability (assessed by means of ECG)? Do responding miRNAs correlate with psychologically perceived stress (assessed by means of VAS)? | — |
Countries
Germany
Contacts
Public ContactPeter Heusser
Lehrstuhl für Medizintheorie, Integrative und Anthroposophische Medizin, Institut für Integrative Medizin, Universität Witten Herdecke
Outcome results
None listed