Repetitive navigated transcranial magnetic stimulation (rnTMS) as therapy option for patients with deteriorated motor function after supratentorial tumor resection

Repetitive navigated transcranial magnetic stimulation (rnTMS) as therapy option for patients with deteriorated motor function after supratentorial tumor resection - TMS therapy study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00010043

Enrollment

Registered

2016-02-15

Start date

2016-03-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G81.9 C71.0

Interventions

Group 1: Intervention group: repetitive navigated transcranial magnetic stimulation (rnTMS) followed by standardized physiotherapy for 7 days postoperatively (one time daily). Stimulation algorithm: 9

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.) Patients with status post supratentorial brain tumor resection with a new occurred or progressive paresis postoperatively 2.) Written consent of the patient for participating in the study 3.) older or equal than 18 years

Exclusion criteria

Exclusion criteria: 1.) Patients with contraindication for MRI-imaging 2.) Patients with contraindication for TMS examination (e.g. metallic implants) 3.) More than one generalized seizure per week 4.) Pregnancy 5.) Disagreement of the patient for participating in the study 6.) younger than 18 years

Design outcomes

Primary

Measure	Time frame
Fugl Meyer assessment of the upper extremity after 3 months, assessed by an experienced blinded physiotherapist.	—

Secondary

Measure	Time frame
Fugl Meyer Assessment of the upper extremity postoperatively, on day of discharge and after 1 month, assessed by an experienced blinded physiotherapist. Nine Hole Peg Test (NHPT), Finger Tapping Test, Karnofsky Performance Status Scale (KPS), muscle strength (BMRC) postoperatively, on day of discharge, after 1 and 3 months, assessed by an experienced blinded physiotherapist. National Institutes of Health Stroke Scale (NIHSS), Karnofsky Performance Status Scale (KPS) postoperatively, on day of discharge, after 1 and 3 months, assessed by a blinded physician. Quality of life (EORTC questionnaire) postoperatively, on day of discharge, after 1 and 3 months. Duration between tumor resection and receiving adjuvant therapy	—

Measure

Time frame

Fugl Meyer Assessment of the upper extremity postoperatively, on day of discharge and after 1 month, assessed by an experienced blinded physiotherapist. Nine Hole Peg Test (NHPT), Finger Tapping Test, Karnofsky Performance Status Scale (KPS), muscle strength (BMRC) postoperatively, on day of discharge, after 1 and 3 months, assessed by an experienced blinded physiotherapist. National Institutes of Health Stroke Scale (NIHSS), Karnofsky Performance Status Scale (KPS) postoperatively, on day of discharge, after 1 and 3 months, assessed by a blinded physician. Quality of life (EORTC questionnaire) postoperatively, on day of discharge, after 1 and 3 months. Duration between tumor resection and receiving adjuvant therapy

—

Countries

Germany

Contacts

Public ContactTizian Rosenstock

Klinik für Neurochirurgie Charité - Universitätsmedizin Berlin

tizian.rosenstock@charite.de+4930450660349

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 6, 2026