WItten heaRt failurE in Aortic Stenosis study - Prospective diagnostic study to investigate the hemodynamic basis of an irreversible left ventricular failure in severe aortic stenosis

WItten heaRt failurE in Aortic Stenosis study - Prospective diagnostic study to investigate the hemodynamic basis of an irreversible left ventricular failure in severe aortic stenosis - WIREAS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00009993

Enrollment

Registered

2016-02-16

Start date

2015-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I35.0 I42.8

Interventions

Group 1: Invasive and non-invasive hemodynamic analyzes in patients with severe aortic stenosis (valve area 40 mmHg before aortic valve replacement. Non-invasive hemodynamic analyzes 3 months after a

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria study group aortic stenosis and left ventricular failure - Severe aortic stenosis ( valve area 1 years - Consent to participate in the study Inclusion criteria control group aortic stenosis without left ventricular failure - Severe aortic stenosis ( valve area 1 years - Consent to participate in the study

Exclusion criteria

Exclusion criteria: - Active endocarditis - Previous heart surgery - Concurrent serious stenosis or insufficiency of the mitral valve - Concurrent serious insufficiency of the aortic valve - Pregnancy, lactation

Design outcomes

Primary

Measure	Time frame
Comparison of reversible and irreversible left ventricular failure in terms of the end-systolic pressure-volume relationship (ESPVR) - measured with conductance catheter - before aortic valve replacement	—

Secondary

Measure	Time frame
Comparison of reversible and irreversible left ventricular failure: - All-cause mortality (one-year) - Cardiovascular mortality (one-year) - Hospitalization for heart failure (within the first year after aortic valve replacement) - Distance in the 6-minute walk test before and 3 months after aortic valve replacement	—

Countries

Germany

Contacts

Public ContactMichael Gotzmann

Kardiogische Klinik, Marien-Hospital Witten, Ruhr-Universität Bochum

michael.gotzmann@rub.de++ 49 (0) 2303 173 3875

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026