VITAMIN B12 MALNUTRITION
Conditions
Interventions
Group 1: Vegan dietary supplement containing synthetic vitamin B12
Dosage: 1 pill daily = 2,5 µg vitamin B12/day
intake over a period of eight weeks
Group 2: Vegan dietary supplement containing pure Chlorella vulgaris
Dosage: 8 pills daily = 2,5 µg vitamin B12/day
intake over a period of eight weeks
Group 3: Vegan dietary supplement containing primarily sea buckthorn, quinoa, quitch
Dosage: 9g/day = 2,5 µg vitamin B12/day)
intake over a period of eight weeks
Sponsors
Institut für Lebensmittelwissenschaft und Humanernährung
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Non-smokers; vegetarian and / or vegan diet for at least 1 years; serum cobalamin range between 110-310 pmol/l; written consent after information about study contents and study procedure; Ability and willingness of study participants to follow study leaders instructions
Exclusion criteria
Exclusion criteria: Intake of vitamin B12-containing dietary supplements 3 month before study begin; severe chronic illness (Cancer, diabetes mellitus Typ I, manifest coronary heart disease), severe kidney or liver diseases; Allergies or intolerances regarding study product contents; chronic gastroinestinal diseases (especially small intestine e.g. duodenal ulcer, liver, pancreas) and state after gastrointestinal surgical procedure e.g. nontropical sprue, short bowel syndrome); Heart or gastrointestinal surgery; immediate planned surgery; BMI >30 kg/m²; addiction to alcohol and/or drugs; smoking; Pregnancy and lactation; missing consent or refusing / reset of the consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in holotranscobalamin (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter) | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in serum cobalamin (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter); Changes in methylmalonic acid (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter); Changes in folic acid (week 8 (t8) in comparison to week 4 (t4); week 8 (t8) in comparison to baseline (t0); week 4 (t4) in comparison to baseline (t0)) (blood parameter) | — |
Countries
Germany
Contacts
Public ContactIsabel Behrendt
Institut für Lebensmittelwissenschaft und Humanernährung
Outcome results
None listed