Effect of waterpipe-use on vascular endothelial function.

Effect of waterpipe-use on vascular endothelial function. - Shisha acute

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009966

Enrollment

Registered

2016-01-28

Start date

2016-02-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers vascular endothelial damage due to Smoking.

Interventions

Group 1: healthy participants before and after 30 minutes shisha smoking Group 2: historical comparison of persons after cigarette smoking Group 3: Probands before and after e-cigarette smoking from t

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: healthy smokers and non-smokers

Exclusion criteria

Exclusion criteria: •History of asthma or chronic pulmonary disease •Smoking of tobacco products within the preceding 12 hours •Current use of long acting nitrates or calcium antagonists •Vascular or other abnormalities precluding application of a pressure cuff on the arm to conduct FMD/FMC measurement •symptomatic cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Flow-mediated Dilation FMD % of the brachial artery (sonographically) before and after smoke exposure	—

Secondary

Measure	Time frame
FMC (flow mediated contraction as described by Gori measured by ultrasound corresponding to FMD) measured before and after vapor exposure; blood pressure measured with Riva-Roci and contiously before , during and after vapor exposure using pulse transit time heart rate (ECG derived, holter monitoring before and during exposure) sympathic nerve activity (laser Doppler before and after exposure) sympathovagal Balance (derived from ECG heart variability measured with holter ECG during study period) Effect of antioxidative substances on FMD (measured as effect of p.o. VitC application on FMD after exposure) Endothelium activation (measured in blood before and after vapor from frozen samples with the use of ELISA kits (E-selectine, VCAM etc.)) Leucocyte and platelet activation (FACS); Thermography of hand Oxidative stress (measured from frozen blood samples befor and after exposure with ELISA	—

Measure

Time frame

FMC (flow mediated contraction as described by Gori measured by ultrasound corresponding to FMD) measured before and after vapor exposure; blood pressure measured with Riva-Roci and contiously before , during and after vapor exposure using pulse transit time heart rate (ECG derived, holter monitoring before and during exposure) sympathic nerve activity (laser Doppler before and after exposure) sympathovagal Balance (derived from ECG heart variability measured with holter ECG during study period) Effect of antioxidative substances on FMD (measured as effect of p.o. VitC application on FMD after exposure) Endothelium activation (measured in blood before and after vapor from frozen samples with the use of ELISA kits (E-selectine, VCAM etc.)) Leucocyte and platelet activation (FACS); Thermography of hand Oxidative stress (measured from frozen blood samples befor and after exposure with ELISA

—

Countries

Germany

Contacts

Public ContactHannelore Seiler

Universitätsmedizin Mainz

hannelore.seiler@unimedizin-mainz.de06131-172476

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026