I63.0 J18.9 N39.0
Conditions
Interventions
Group 1: Aim of this study is to show a possible protective effect of prior and continued beta-blocker therapy on infection rates after acute ischemic stroke
Group 2: The control group includes patien
Sponsors
Klinik für Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Ischemic stroke in the insular and/or anterior-medial Cortex with an index NIHSS>4 Age >18 and <80 years
Exclusion criteria
Exclusion criteria: -Systemic infection at baseline (index stroke) (elevated body temperature, leukocytosis >12*10^3 or C-reactive protein >10 mg/dl) -Stroke onset >12 prior to admission -Malignant primary disease -Primary disease associated with immunodepression -History of immunodepression (cytostatic-therapy within 1 month prior to index stroke, leukocytes 3 -Intracraneal hemorrhage -Surgery within 30 days prior to index stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Co-primary endpoint consisting of post-stroke pneumonia an urinary tract infection within 7 days after acute ischemic stroke according to diagnostic criteria of current guidelines | — |
Secondary
| Measure | Time frame |
|---|---|
| - Stroke outcome (modified Rankin Scale at baseline, after 7- and 30 days, National Institute of Health Stroke Scale at baseline and after 7 days) - Infection-parameters (C-reactive protein and leukocyte-count after 7 days) - Death | — |
Countries
Germany
Contacts
Public ContactIlko Maier
Klinik für Neurologie
Outcome results
None listed