Fluid management during laparoscopic cholecystectomy Oxidative stress and immune response in acordance to fluid management during laparoscopic cholecystectomy
Conditions
Interventions
Group 1: Patients under general anesthesia undergoing laparoscopic cholecystectomy that will during surgery receive restrictive ( 1ml/kg/hour ) volume of crystalloid solution (Ringer Solution – B. Bra
Sponsors
General Hospital Karlovac
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ASA (American Society of Anesthesiology) status I and II (low perioperative risk patients) patients that will undergo laparoscopic cholecystectomy
Exclusion criteria
Exclusion criteria: Patients younger than 18 and older than 65 years of age will be excluded from study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyse perioperative changes in total antioxidant status (TAS) and IL-6 plasma levels in accordance to restrictive or liberal perioperative volume management, assessed before operation, at the time of reaching pneumoperitoneum, 6 hours after surgery and 24 hours after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| To analyse perioperative hemodynamic stability by continuous monitoring of Systolic (SAP), Diastolic (DAP) and mean arterial blood pressure (MAP), Heart rate, Stroke Volume and Cardiac Output Dynamic Preload parameters (Pulse Pressure Variation (PPV) and Stroke Volume Variation (SVV)) in accordance to restrictive or liberal volume management. | — |
Countries
Croatia
Contacts
Public ContactPetar Miskovic
General Hospital Karlovac
Outcome results
None listed