major chronic depression F33
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: - diagnosis of Chronic Depression - Hamilton Rating Scale of Depression (HRSD-24) score>20 - in ongoing medical/psychiatric care - age 18-70 years - fluent in German language - technical requirements (Internet access) - informed consent - treatment resistance (no response to two or more adequate trials of antidepressants and/or no response to at least two health-insurance-reimbursed psychotherapies with at least 22 sessions each).
Exclusion criteria
Exclusion criteria: - history of bipolar disorder - substance addiction (less than 3 months clean) - antisocial or borderline personality disorder - severe autism - organic brain disorders - severe physical illness - acute risk of suicide or suicide attempt within the last 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Questionnaire on feasibility and acceptance. Completed by patients and therapists - Hamilton Rating Scale for Depression (HAMD-24; Hamilton, 1960) T0, T1, T2, T3 (T0 : at admission to station , T1 : at discharge from station , T2 : at end of outpatient therapy , follow-up ( T3 ) : 3 months after completion of outpatient therapy (end of study) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Structured Clinical Interview for DSM-IV Disorders (T0). - Childhood Trauma Questionnaire (T0). - Beck Depression Inventory (T0-T3). - Clinical Global Impression Scale (T1-T2). - Global Assessment of Functioning Scale (T1-T2). - World Health Organization Quality of Life Instrument (T0-T3). - Impact Message Inventory-R (therapist-patient-relationship) (T1-T2). | — |
Countries
Germany
Contacts
Universitätsklinikum FreiburgKlinik für Psychiatrie und Psychotherapie