postprandial metabolism
Conditions
Interventions
Group 1: Meal 1: rich in fat and saturated fatty acids (single consumption in the morning), 14 days wash-out period between each test meal
Group 2: Meal 2: rich in carbohydrates (single consumption in
Sponsors
Universität BonnIEL Ernährungsphysiologie
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Non smoking, Overweight/obesity (BMI 27-34,9 kg/m2), Visceral adiposity, Dyslipidemia, Pro-inflammatory state , Raised blood glucose, Prehypertension or stage 1 hypertension
Exclusion criteria
Exclusion criteria: Malabsorption syndromes, unmedicated thyroidal diseases, impaired function of the kidney, secondary hypertension, chronic liver-diseases, heart insufficiency, Prior myocardial infarction, insulin treated Diabetes Mellitus, untreated Diabetes insipidus, chronic inflammatory diseases including rheumatoid arthritis, presence of any tumors, chronic intake of nutrient-supplements, alcoholic abuse, medical abuse, immune suppression
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameter of endothelial function, inflammation, oxidation and lipid and glucose metabolism; Fasting and postprandial hourly measurements for five hours | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure (fasting, postprandial), determining apolipoprotein E (apoE) genotype and its effect of on primary study variables, plasma concentrations of neurofilament light (nfl) and tau protein, metabolomics analyses | — |
Countries
Germany
Contacts
Public ContactSarah Egert
Universität Bonn IEL Ernährungsphysiologie
Outcome results
None listed