Research study to establish whether the transfer of Methadone and EDDP in opioid substitution therapy can be achieved via patient perspiration on to drug-free hair, in parallel with a comparison study of the relationship between methadone doses and the concentration of methadone and EDDP found in sweat and blood samples.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009854

Enrollment

Registered

2016-05-23

Start date

2019-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transfer of Methadone from sweat of patiens undergoing substitution therapy on substance-free hair Correlation of Methadone-dose and concentration in blood-/sweat-samples

Interventions

Group 1: The purpose of our study is, therefore, to discover whether the transfer of traces of methadone and its metabolite EDDP (2-Ethyliden-1,5-dimethyl-3,3-dipheny-ipyrrolidine) can be effected fro

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Ability to consent Legal age Ability to conceive and understand the basic informations Consent to voluntary blood taking Medically indicated methadone-therapy Stable methadone-dose Motivation Exercise capacity Reliability

Exclusion criteria

Exclusion criteria: Nonage Lack of compliance

Design outcomes

Primary

Measure	Time frame
Proof of transfer of methadone and its metabolite EDDP from the sweat of test subject patiens onto substance-free hair with GC/MC –methods. The results oft the hair- and sweat-samples would be compared with data obtained from test subjects’ blood samples, with the intention of determining whether a relationship can be established with the detected methadone and EDDP concentrations and whether a hypothetical extreme value can be established. During the five study-days a strand of hair and a sweat patch would be removed each day, in order to detect the variation in concentration of substances with respect to exposure time.	—

Measure

Time frame

Proof of transfer of methadone and its metabolite EDDP from the sweat of test subject patiens onto substance-free hair with GC/MC –methods. The results oft the hair- and sweat-samples would be compared with data obtained from test subjects’ blood samples, with the intention of determining whether a relationship can be established with the detected methadone and EDDP concentrations and whether a hypothetical extreme value can be established. During the five study-days a strand of hair and a sweat patch would be removed each day, in order to detect the variation in concentration of substances with respect to exposure time.

—

Countries

Germany

Contacts

Public ContactKatharina Feld

Institut für Rechtsmedizin

katharina.feld@uk-koeln.de0221 478-88338

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026