SIRS -(systemic inflammatory Response Syndrome) and development of complications, such as Sepsis, after cardiac surgery R65
Conditions
Interventions
Group 1: Patients undergoing off pump coronary artery Bypass (OPCAB) surgery will serve as control. NETs Level in the control group will be compared to those measured in patients undergoing cardiopulm
Sponsors
Herzzentrum der Universität zu KölnKlinik für Herz- und Thoraxchirurgie
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Written informed consent from all participants or their legal representatives
Exclusion criteria
Exclusion criteria: - patients with known preexisting immunological disorders or systemic immunosuppressive medication -no consent -<18
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood samples will be collected from patients undergoing cardiac surgery at the day of admission, pre-OP, post-OP as well as at days 1, 3,, 5, 8 and 10 after surgery. NETs levels in patients' Plasma will be quantified by photometry and Real Time PCR, respectively. | — |
Secondary
| Measure | Time frame |
|---|---|
| The scoring Systems CASUS, SOFA and APACHEII will be calculated. Plasma NETs level will be correlated to patients' scores | — |
Countries
Germany
Contacts
Public ContactAdnana Paunel-Görgülü
Herzzentrum der Universität zu Köln
Outcome results
None listed