I10.00
Conditions
Interventions
Group 1: (-)-Epicatechin, 1 capsule = 25 mg/day p.o., 14 days, followed by 14 days wash-out
Group 2: Placebo (mannit), 1 capsule/day p.o., 14 days, followed by 14 days wash-out
Sponsors
Hochschule Niederrhein
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age: 18-65 years; non-smokers; increased cardiovascular risk: overweight or obesity (BMI = 25 kg/m2); blood pressure =130/85 mmHg without medical treatment; slightly increased blood glucose or triglycerides or cholesterol; written informed consent for participation
Exclusion criteria
Exclusion criteria: Intake of statines, oral antidiabetics or antihypertensiva, intended weight reduction, supplementation of vitamin C, E, beta-carotene aswell as polyphenolrich extracts e.g., from green tea cocoa, red wine, cranberries. Participation in another study/clinical trial simultaneously or within the last 30 days. Known pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical blood pressure (systolic/diastolic), determined after an overnight fast. Measured before and after every "intervention". That menas: blood pressure was measured before and after the administration of placebo and active compound | — |
Secondary
| Measure | Time frame |
|---|---|
| Vascular elasticity (sonography), blood lipids, carbohydrate metabolism (glucose, insulin), oxidized LDL (ELISA), vitamin C, E, beta-carotene (HPLC), arginine (MS), (-)-epicatechin (HPLC). Measured before and after every intervention (active compund and placebo) | — |
Countries
Germany
Contacts
Public ContactNatalie Kirch
Hochschule Niederrhein
Outcome results
None listed