I60.1 S06 I63.1 I61.0
Conditions
Interventions
Group 1: mechanical ventilation in a pressure-controlled mode for 3 hours
Group 2: mechanical ventilation in a volume-controlled mode for 3 hours
Sponsors
Klinikum Kassel, Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - need for mechanical ventilation - need for ICP monitoring - written informed consent by legal proxy
Exclusion criteria
Exclusion criteria: - assisted breathing, spontanious breathing - severe respiratory failure (FiO2 10mmHg) - elevated ICP > 25mmHg and need for ICP therapy within the last 6 hours - Circulatory shock: shock index >1 (Heart frequency/ systolic blood pressure) within the last 6 hours - fever: body temperature >= 38,5°C within the last 6 hours - acidosis: PH 500mg/dl within the last 6 hours - severe respiratory diseases such as lung fibrosis or COPD - prone positioning
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| - mean ICP and CPP (cerebral perfusion pressure) values - frequency of ICP increases above critical values of 20 mmHg or more - frequency of CPP decreases of 50 mmH or lower - need for ICP therapy - frequency of respiratory complications. | — |
Primary
| Measure | Time frame |
|---|---|
| fluctations of ICP (intracranial pressure) values during pressure-controlled mode ventilation compared to volume-controlled mode ventilation. ICP is measured continuously via intraparenchymatous ICP monitoring. This study had no influence on the indication of ICP monitoring. | — |
Countries
Germany
Contacts
Public ContactChristian Roth
Klinikum Kassel, Neurologische Klinik
Outcome results
None listed