F32 F33
Conditions
Interventions
Group 1: Family study investigating the inheritance of epigenetic modifications (DNA methylation) in CpG-rich regions within candidate genes (ABCB1, FKBP5, P2RX4, P2RX5) between children and adolescen
further, methylation rate in CpG-rich gene regions will be examined. Genetically and epigenetically inherited information will be compared between case and control families.
Sponsors
Max-Planck-Institut für Psychiatrie
Eligibility
Sex/Gender
All
Age
3 Years to 17 Years
Inclusion criteria
Inclusion criteria: Children and adolescents of both sexes aged 3 to 17 years, balanced in age and sex distribution between cases and controls; study consent of at least one parent or guardian of the study participant as well as oral and / or written consent of the minor study participant.
Exclusion criteria
Exclusion criteria: Pervasive developmental disorder in study participants (ICD10 F84)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Association of methylation rates between child and mother or father separately for families with and without maternal depression. The objective is to identify those genetic loci that allow the strongest separation of both groups of families. The analysis is focussed on DNA methylation in CpG-rich regions of the genes ABCB1, FKBP5, P2RX4 and P2RX7. | — |
Secondary
| Measure | Time frame |
|---|---|
| Allelci transmission rates of the candidate genes ABCB1, FKBP5, P2RX4 and P2RX7 from parents to child separately for families with and without maternal depression. | — |
Countries
Germany
Contacts
Public ContactMarcus Ising
Max-Planck-Institut für Psychiatrie
Outcome results
None listed