Attentional processes and decision making in social interactions - Investigation of alterations in individuals with Borderline Personality Disorder and the relationship to different hormones

Attentional processes and decision making in social interactions - Investigation of alterations in individuals with Borderline Personality Disorder and the relationship to different hormones - Social_Perception 2

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009815

Enrollment

100

Registered

2016-01-11

Start date

2016-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers F60.31

Interventions

Group 1: BPD-Oxytocin condition: 25 female patients with BPD, one intranasal Administration of 24 I.U. oxytocin

after clinical diagnostic interviews (International Personality Disorder Examination

Loranger et al. 1994 and SCID-I) as well as several dimensional questionnaires for the assessment of clinical symptoms and personality traits (Borderline-Symptom-Liste

Bohus et al., 2007

Zanarini Scale

Zanarini et al. 2003

German Version of the Difficulty in Emotion Regulation Scale

Gratz et al., 2004

German version of the Childhood Trauma Questionnaire

Bernstein et al., 1998

German version of the State-Trait Anger Inventory

Spielberger, 1991

German Version of the State-Trait Anxiety Inventory

Laux et al., 1981

German version of the Barrat Impulsivity Scale

Patton et al., 1995

Dissociation

Freyberger, 1999

Multidimensional Mood Questionnaire

Steyer et al. 1997

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: General inclusion criteria: age 18-50 years, readiness for participation. Additional inclusion criterion for patients with Borderline Personality Disorder: Borderline Personality Disorder assessed with the International Personality Disorder Examination.

Exclusion criteria

Exclusion criteria: General exclusion criteria: actual pregnancy, lifetime diagnosis of any psychotic or bipolar disorders, substance dependence during the past year, a history of brain damage, severe internistic or neurological disease, claustrophobia. Additional exclusion criterion for healthy controls: more than one DSM-IV criterion for Borderline Personality Disorder fulfilled.

Design outcomes

Primary

Measure	Time frame
Behavioral Data: Performance and reaction time; EEG: P1, N170, P300 for emotional faces after a single oxytocin vs. placebo administration in female BPD patients vs. healthy controls	—

Secondary

Measure	Time frame
Exploratory correlations between behavioral and EEG data (see Primary outcome) and dimensional trait questionnaires (anger, German version of the State-Trait Anger Inventory; Spielberger, 1991; anxiety, German Version of the State-Trait Anxiety Inventory; depression, Beck Depression Inventory; aggressiveness, Life History of Aggression Inventory; Coccaro et al. 1997; Overt Aggression Sale Modified for Outpatients; OAS-M, Coccaro et al., 1991) after single oxytocin vs. Placebo Administration in female BPD patients vs. healthy volunteers.	—

Measure

Time frame

Exploratory correlations between behavioral and EEG data (see Primary outcome) and dimensional trait questionnaires (anger, German version of the State-Trait Anger Inventory; Spielberger, 1991; anxiety, German Version of the State-Trait Anxiety Inventory; depression, Beck Depression Inventory; aggressiveness, Life History of Aggression Inventory; Coccaro et al. 1997; Overt Aggression Sale Modified for Outpatients; OAS-M, Coccaro et al., 1991) after single oxytocin vs. Placebo Administration in female BPD patients vs. healthy volunteers.

—

Countries

Germany

Contacts

Public ContactSabrina Boll

Klinik für Allgemeine Psychiatrie Universitätsklinikum Heidelberg

sabrina.boll at med.uni-heidelberg.de06221 5634861

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026