j32.4
Conditions
Interventions
Group 1: - topical nasal steroid (2 x 2 puffs daily) for 12 months
- nasal douches 3 x daily
- antibiotics (cephalosoprin i.v. preoperatively, Doxycyclin 100 mg OD, if allergic Cotrim forte 2 x 960 mg
Sponsors
HNO-KlinikUniklinik Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Age >/= 18 years - bilateral endonasal endoscopic sinus surgery: maxillary sinusotomy, anterior and posterior ethmoidectomy, frontal sinus drainage Draf IIa - chronic rhinosinusitis with nasal polyps not responding to medical treatment (at least topical steroids for 6 weeks, nasal douches, antibiotics for 3 weeks if indicated, systemic steroids if indicated) - informed consent - compliance with the study protocol
Exclusion criteria
Exclusion criteria: - no consent - diseases that affect wound healing (AIDS, cystic fibrosis, immune deficiency, neutropenia) - coagulation disorders or anticoagulants up to 7 days preoperatively - indications for sinus surgery other than CRSwNP
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: sinunasal wound healing 2 weeks postoperatively according to endoscopic score by Valentine 2010. Hypothesis: Occlusion of the nose will lead to a faster wound healing after endoscopic sinus surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome: - patient comfort measured by VAS 2, 3, 4, 12 weeks and 1 year postoperatively - sinunasal wound healing after 3, 4, 12 weeks and 1 year after surgery according to endoscopic score by Valentine 2010 - the duration of each aftercare visit in minutes 2, 3, 4 weeks postoperatively -size of the maxillary and frontal sinus neo-ostium in mm 3 months and 1 year postoperatively meassured with 3 mm suction instrument | — |
Countries
Czechia, Germany
Contacts
Public ContactTanja Hildenbrand
HNO-KlinikUniklinik Freiburg
Outcome results
None listed