CHRONIC OBSTRUCTIVE PULMONARY DISEASE J44
Conditions
Interventions
Group 1: A 16-week eccentric training. Training session will be carried out 3 times per week. They will start from 5 min and progress up to 30 min of cycling. Intensity will be progressively increased
Sponsors
Universidad Finis Terrae
Eligibility
Sex/Gender
Male
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: All participants will obtain medical clearance from a physician before taking part in the current study. Participants will have no history of participating in any structured exercise training program designed to improve leg strength or power over the previous 6 months, and will be willing to undertake 16 weeks of training without interruption and attend all testing sessions.
Exclusion criteria
Exclusion criteria: Exclusion criteria will include current insulin therapy, long-term oxygen therapy, asthma, other concomitant pulmonary diseases or other diseases that could affect physical activity, such as neurological diseases, kidney diseases, symptomatic cardiovascular diseases, left cardiomyopathy, musculoskeletal and neuromuscular diseases. Also, illness that could cause death within 6 months, inability to perform the tests, unstable angina or congestive heart failure stage III or IV will be considered exclusion criteria (Gutie´rrez et al., 2007; Pavie´ et al., 2011).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the health benefits after 16 weeks of three different exercise modalities (eccentric cycling, concentric cycling and resistance training) on the oxidative stress (plasma TBARS,total glutathione, gluthatione peroxidase, protein carbonyl and total antioxidant capacity) chronic inflammation (TNF-alpha, IL-1 and IL-6) and metabolic disease (Glycemic control, insulin sensitibity, lipid profile, body composition, muscle function) biomarkers of patients with COPD. Measurements will be performed before and 72 h after the completion of 16 weeks of training. | — |
Secondary
| Measure | Time frame |
|---|---|
| Examine the changes in muscle strength and endurance before and 72 h after the completion of 16 weeks of training. Knee extensor muscle strength will be assessed by maximal isometric voluntary contractions at 70º of knee flexion. Endurance will be assessed by a time trial test in a concentric ergometer assessed as the maximum time last cycling at 80% of the VO2max. | — |
Countries
Chile
Contacts
Public ContactSantiago Aranguiz
Universidad Finis Terrae
Outcome results
None listed