C16.9 K58.1 K59.0 K30 G30 C25.9 C18.9
Conditions
Interventions
Group 1: Analysis of gut microbiota and exact clinical characterization of healthy elderly:
subgroup 40-49 years
subgroup 50-59 years
subgroup older than 60 years
Group 2: Analysis of gut microbiota
Sponsors
Otto-von-Guericke Universität MagdeburgMedizinische Fakultät
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Healthy subjects: Age > 40 Years Patients with gastric cancer: Histologically confirmed Adenocarcinoma of the stomach Patients with pancreatic cancer: Histologically confirmed Adenocarcinoma of the pancreas UICC I-IV Patients with colorectal cancer: Histologically confirmed colorectal carcinoma UICC I-IV Patients with functional dyspepsia or irritable bowel Syndrom (IBS): funcional dyspepsia or IBS according to the Rom-III-criteria Patients with demenia: confirmed diagnosis of dementia or neurodegenerative disease Partner of Patient with dementia: person living in households with the patient with the diagnosis of dementia
Exclusion criteria
Exclusion criteria: Healthy subjects: neurodegenerative diseases; functional gastrointestinal diseases; tumor disease in the last 5 years; Serious metabolic or cardiovascular disease requiring therapy (Diabetes mellitus, thyroid disorders, disorders of lipid metabolismus), a medicamentous well-treated arterial hypertension does not represent an exclusion criterium; antibiotic therapy within the last 8 weeks Patients with gastric cancer: additional other tumor disease; antibiotic therapy within the last 8 weeks Patients with pancreatic cancer: additional other tumor disease; antibiotic therapy within the last 8 weeks Patients with colorectal cancer: additional other tumor disease; antibiotic therapy within the last 8 weeks Patients with functional dyspepsia or irritable bowel Syndrom (IBS): antibiotic therapy within the last 8 weeks; past extensive abdominal operations, chemotherapy, radiotherapy or immunsuppressive therapy within the last 2 years Patients with dementia: antibiotic therapy within the last 8 weeks; Partner of Patient with dementia: antibiotic therapy within the last 8 weeks; tumor disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyze the differences in the composition of gut microbiome in the gastrointestinal tract with regard to the dominant Genera between elderly and patients with functional gastrointestinal diseases, gastric, pancreatic and colorectal cancer, or neurodegenerative diseases. | — |
Secondary
| Measure | Time frame |
|---|---|
| to analyse: - How does the gut microbiota change during aging? - How does the mucosa-adherent microbiome differ from fecal microbiome after bowel-cleansing ? - Which enviromental factors influence the differences in gut microbiota composition? (residence location in the community, nutrition)? - How does the gut microbiota influence pro- /antiinflammatory mucosal processes? - Does an influence of the gut microbiota on systemic inflammation in the above mentioned populations exist? - How do the above mentioned populations differ with regard to the nutritional anamnesis and the nutritional assessment, and how do these factors influence the gut microbiota? - Can interventional models be developed as a result of the differences detected between the selected populations aiming at therapeutic interventions to correct disease-related dysbiosis? | — |
Countries
Germany
Contacts
Public ContactChristian Schulz
Klinik für Gastroenterologie, Hepatologie und InfektiologieOtto-von-Guericke Universität Magdeburg
Outcome results
None listed