Acute effects of eccentric cycling on systemic inflammation, oxidative stress and muscle damage markers in COPD patients

Acute effects of eccentric cycling on systemic inflammation, oxidative stress and muscle damage markers in COPD patients - ECC and COPD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009711

Enrollment

Registered

2016-03-29

Start date

2016-04-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CHRONIC OBSTRUCTIVE PULMONARY DISEASE J44

Interventions

Group 1: COPD patients: Investigation of the acute responses of two 30-min bouts of eccentric cycling and one 30-min bout of concentric cycling performed at 50% VO2max on systemic inflammation and oxi

Eligibility

Sex/Gender

Male

Age

40 Years to 90 Years

Inclusion criteria

Inclusion criteria: All participants will obtain medical clearance from a physician before taking part in the current study. Participants will have no history of participating in any structured exercise training program designed to improve leg strength or power over the previous 6 months, and will be willing to undertake 16 weeks of training without interruption and attend all testing sessions.

Exclusion criteria

Exclusion criteria: Exclusion criteria will include current insulin therapy, long-term oxygen therapy, asthma, other concomitant pulmonary diseases or other diseases that could affect physical activity, such as neurological diseases, kidney diseases, symptomatic cardiovascular diseases, left cardiomyopathy, musculoskeletal and neuromuscular diseases. Also, illness that could cause death within 6 months, inability to perform the tests, unstable angina or congestive heart failure stage III or IV will be considered exclusion criteria (Gutie´rrez et al., 2007; Pavie´ et al., 2011).

Design outcomes

Primary

Measure	Time frame
To investigate acute effects of two bout of eccentric cycling and one concentric cycling on the oxidative stress (plasma TBARS, protein carbonil, 8-iso-prostaglandin, total gluthatione, gluthatione peroxidase, total antioxidant capacity) and systemic inflammation (Il-6, TNF-alpha) biomarkers of patients with COPD before, immediately after, 24, 48, 72 and 96 h after exercise	—

Secondary

Measure	Time frame
Examine the acute metabolic stress (oxygen consumption and saturation during cycling) and muscle damage markers (CK and muscle strength) before and 24, 48, 72 and 96 h after exercise	—

Countries

Chile

Contacts

Public ContactSantiago Aranguiz

Universidad Finis Terrae

saranguiz@uft.cl(+56) 2 2420 7226

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026