Capillary Leak in Burn Patients

Capillary Leak in Burn Patients - CLIB

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00009686

Enrollment

Registered

2015-11-20

Start date

2017-11-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T29.0 T79

Interventions

Group 1: Patients with a burn trauma of equal to / greater than 20 % of their body surface will be observed. Evaluation of biochemical variables will be performed: blood fragments of the vascular bar

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: - burn injury equal / larger than 20% of body surface area

Exclusion criteria

Exclusion criteria: - Patient suffered burn trauma longer than 24 h ago - Further traumata in the sense of polytrauma - Any other condition deemed unsuitable by the Medical Director for study inclusion - Refusal of inclusion by the patient, his legal guardian or the consultant in charge of the initial inclusion

Design outcomes

Primary

Measure	Time frame
Primary outcome variables are variables defining microcirculatory failure: 1. endothelial dysfunction, 2. capillary leak, 3. proteinuria. The observation period of the study will be 196 h from patient admission. All variables, defined under points 1 - 3, will be measured at the following time points during the study: at admission on the intensive care unit and after 6, 12, 24, 48, 96 and 192 hours after admission. 1. defined by blood concentrations of syndecan-1, glycosaminoglycans, endostatin, cathepepsin-L, tumstatin, matrix-metalloproteinase 2, matrix-metalloproteinase 9 2. defined by tissue ultrasound meausrements based on the concept of Suehiro et al. (Annals of vascular diseases. 2013:6(2):180-8) 3. content of total proteins in 24h urine collection	—

Measure

Time frame

Primary outcome variables are variables defining microcirculatory failure: 1. endothelial dysfunction, 2. capillary leak, 3. proteinuria. The observation period of the study will be 196 h from patient admission. All variables, defined under points 1 - 3, will be measured at the following time points during the study: at admission on the intensive care unit and after 6, 12, 24, 48, 96 and 192 hours after admission. 1. defined by blood concentrations of syndecan-1, glycosaminoglycans, endostatin, cathepepsin-L, tumstatin, matrix-metalloproteinase 2, matrix-metalloproteinase 9 2. defined by tissue ultrasound meausrements based on the concept of Suehiro et al. (Annals of vascular diseases. 2013:6(2):180-8) 3. content of total proteins in 24h urine collection

—

Secondary

Measure	Time frame
Secondary endpoints: - Pulmonary edema found in chest x-ray - Intra-abdominal pressure - Body weight - Cumulative Fluid balance - Blood NTpro-BNP - Blood TNF-alpha	—

Countries

Germany

Contacts

Public ContactUlrich Limper

Universität Witten/Herdecke Lehrstuhl für Anästhesiologie II und Deutsches Zentrum für Luft- und Raumfahrt, Institut für Luft und Raumfahrtmedizin

ulrich.limper@dlr.de022036013063

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026