right ventricular load I27 J44
Conditions
Interventions
Group 1: PET/CT scan of patients with ideopathic pulmonary hypertension using a specific SERT-radiotracer
Group 2: PET/CT scan of patients with severe pulmonary hypertension and COPD using a specific
Sponsors
Universitätsklinikum Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: All participants: - Age between 18 and 70 years - ?/? subgroup 1 - patients with ideopathic pulmonary hypertension - pulmonary artery catheterization within the last 6 months - no specific medication within initial diagnosis - no structural pulmonary disease subgroup 2 -patients with severe pulmonary hypertension with COPD - COPD GOLD III and IV, resp. group C and D without exacerbation - pulmonary artery catheterization within the last 6 months - no specific medication within initial diagnosis subgroup 3 - patients with comparable COPD without pulmonary hypertension - COPD GOLD III and IV, resp. group C and D without exacerbation - echocardiographical exclusion of pulmonary hypertension subgroup 4 - healthy controls: - echocardiographical exclusion of pulmonary hypertension
Exclusion criteria
Exclusion criteria: - under SSRI medication - acute exacerbation of COPD - right ventricular decompensation - judicially or official ordered custody - pregnancy, breastfeeding - legal incapacity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Based on the PET data it follows the calculation of an activity quotient between tissue and plasma as a direct measure of the distribution volume of the radiotracer and therefore of the transporter availability in the separate individuals | — |
Secondary
| Measure | Time frame |
|---|---|
| comparison of pulmonary SERT-availabilty between the individuals as well as subgroups | — |
Countries
Germany
Contacts
Public ContactHans-Jürgen Seyfarth
Medizinische Klinik und Poliklinik I, Abteilung für PneumologieLeiter: Prof. Dr. med. H. WirtzUniversitätsklinikum Leipzig AöR
Outcome results
None listed