Preventing the progression of Osteoarthritis of the knee Grade 2- 3 by mechanical stimulation with high impact physical exercise training device (GALILEO)

Preventing the progression of Osteoarthritis of the knee Grade 2- 3 by mechanical stimulation with high impact physical exercise training device (GALILEO) - Prev-OP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009677

Enrollment

240

Registered

2016-01-26

Start date

2016-02-26

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M17

Interventions

Group 1: High Impact Exercise - Extensor muscle recovery (EMR) by static and dynamic hypertrophy program followed by high impact exercise (HIE) with resistive vibration exercise (RVE), additionally 50

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: • Women and men in the age between 40 and 80 years • OAK corresponding grad 2 and 3 according to Kellgren and Lawrence score • pain > 40 mm measured with the 100 mm VAS over a minimum of 50 % of time within the last month • Written inform consent

Exclusion criteria

Exclusion criteria: • Knee endoprosthesis at any time • Hip endoprosthesis in the last12 months • in the last five years: malignant diseases, angina pectoris, intervention of the coronary arteries, thromboembolic events (e.g. acute deep vein thrombosis, stroke, myocardial infarct, absolute arrhythmia, uncontrolled hypertension, occlusion of the retinal artery or –vein) • Patients are not be able to perform the investigation conform to the protocol • Patients with cognitive impairment excluding an understanding of the study protocol and /or the self-dependent completion of the questionnaires • Insufficient understanding of the German language • participation in an other clinical study at the same time • existing pregnancy

Design outcomes

Primary

Measure	Time frame
symptoms of OA measured by the WOMAC at baseline (month 0), month 6, month 12, month 18, month 24	—

Secondary

Measure	Time frame
Frequency, duration and intensity of physical activity measured by means of accelerometers and self reports at M0 M12, M24; Physical activity measured by Office in Motion Questionnaire (OIMQ) at M0, M6, M12, M18, M24; Health-related quality of life measured by SF12-SOEP Version at M0, M6, M12, M18, M24; Depressive symptoms measured by CES-D scale at M0, M6, M12, M18, M24; Pain today measured by VAS at M0, M6, M12, M18, M24	—

Measure

Time frame

Frequency, duration and intensity of physical activity measured by means of accelerometers and self reports at M0 M12, M24; Physical activity measured by Office in Motion Questionnaire (OIMQ) at M0, M6, M12, M18, M24; Health-related quality of life measured by SF12-SOEP Version at M0, M6, M12, M18, M24; Depressive symptoms measured by CES-D scale at M0, M6, M12, M18, M24; Pain today measured by VAS at M0, M6, M12, M18, M24

—

Countries

Germany

Contacts

Public ContactHendrikje Börst

Charité Universitätsmedizin Berlin, CBF, Zentrum für Muskel- und Knochenforschung

Hendrikje.boerst@charite.de03084454117

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 6, 2026