Effect of Bardoxolon-Methyl on formation, extent and persistence of in vitro induced DNA damage in human peripheral blood lymphocytes.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00009641

Enrollment

Registered

2015-12-08

Start date

2015-12-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

radiation damage: in vitro lymphocytes

Interventions

Group 1: After venipuncture human peripheral blood is incubated with Bardoxolone. At different time points after addition of Bardoxolone (2h, 6, 30 min) or before (30 min) the blood is exposed against

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: no previous radiation therapy/diagnostics (last 2 years)

Exclusion criteria

Exclusion criteria: previous radiation therapy/diagnostics (2 years)

Design outcomes

Primary

Measure	Time frame
IN VITRO analysis of radiation-induced DNA-damage : symmetrical chromsomsomal translocations in peripheral blood lymphocytes (FISH) and asymmetrical translocations (DCA).	—

Secondary

Measure	Time frame
IN VITRO analysis of radiation-induced DNA-damage (micronucleus formation) in peripheral blood lymphocytes (CBMN). Apoptosis using flow cytometry.	—

Countries

Germany

Contacts

Public ContactChristina Beinke

Institut für Radiobiologie der Bundeswehr

christinabeinke@bundeswehr.org089 992692 2273

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026