Effects of acute inflammatory reaction on immunological and psychological parameters in obese people

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009624

Enrollment

Registered

2015-11-05

Start date

2016-03-22

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E66

Interventions

Group 1: Obese subjects: Injection of 0.8ng/kg body weight Lipopolysaccharide intravenously Group 2: Obese subjects: Injection of 0.8ng/kg body weight NaCl intravenously Group 3: Normal weight subject

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Healthy subjects aged 18-35. People with a Body Mass Index (BMI) of more than 30kg/m2 are assigned to the group of obese subjects; people with a BMI of less than 25kg/m2 are assigned to the group of normal-weight subjects.

Exclusion criteria

Exclusion criteria: Excessive use pf nicotine and alcohol, known chronical infectious diseases like hepatitis B/C and HIV, known cardiovascular diseases like coronary artery disease, known pneumological diseases like COPD or bronchial asthma, malignant tumors, known autoimmune disorders, other relevant and manifest diseases of internal organs, psychiatric disorders, antidepressant/neuroleptic treatment, antiinflammatory or immunsuppressive treatment and pregnancy.

Design outcomes

Primary

Measure	Time frame
ACTH, cortisol, catecholamines, cytokines (IL-1ra, IL- ß, 1IL-6, IL-10, TNF alpha) and adipokines in plasma are measured before and 1, 2, 3, 4, 6, and 24 hours after the injection.	—

Secondary

Measure	Time frame
Before the study psychological parameters are measured by using questionnaires. Questionnaires used: Questionnaire about social support (SOZ-U), Life-Orientation-Test-Revised (LOTR) and neuroticsm-scale of the Neo-personality inventory in the revised version (NEO-PI-R). During the study the subjective rating of state is measured 2, 4 and 6 hours after the injection using standardised questionnaires: Beck-Depression-Inventory II (BDI-II), State-Trait-Anxiety-Inventory (STAI), Profile of Mood States (POMS) and Stanford Sleepiness Scale (SSS). Moreover, during the study the following physiological parameters are measured: body temepratur, blood pressure, heart rate. Additionally, before and 24 hours after the injection, the cognitive parameters reaction time, psychomotoric functioning and inhibitory control are measured by computerized tests (TAP).	—

Measure

Time frame

Before the study psychological parameters are measured by using questionnaires. Questionnaires used: Questionnaire about social support (SOZ-U), Life-Orientation-Test-Revised (LOTR) and neuroticsm-scale of the Neo-personality inventory in the revised version (NEO-PI-R). During the study the subjective rating of state is measured 2, 4 and 6 hours after the injection using standardised questionnaires: Beck-Depression-Inventory II (BDI-II), State-Trait-Anxiety-Inventory (STAI), Profile of Mood States (POMS) and Stanford Sleepiness Scale (SSS). Moreover, during the study the following physiological parameters are measured: body temepratur, blood pressure, heart rate. Additionally, before and 24 hours after the injection, the cognitive parameters reaction time, psychomotoric functioning and inhibitory control are measured by computerized tests (TAP).

—

Countries

Germany

Contacts

Public ContactKaroline Boy

Institut für Medizinische Psychologie und Verhaltensimmunbiologie

karoline.boy@uk-essen.de0201 723 4435

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026