The influence of flow pattern of minimized extracorporeal circulation on end organ function – measurement of microcirculation, endothelial function and hemodynamic energy.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009620

Enrollment

Registered

2015-12-04

Start date

2015-12-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I25.9

Interventions

Group 1: Coronary artery bypass grafting with continuous flow minimized extracorporeal circulation Group 2: Coronary artery bypass grafting with pulsatile flow minimized extracorporeal circulation

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient age > 18 years Patient with coronary heart disease requiring bypass grafting with extracorporeal circulation Calafiore blood cardioplegia Written informed consent

Exclusion criteria

Exclusion criteria: Ejection fraction 10 mg/l or WBC > 12x109/l) Malignant or immunological diseases

Design outcomes

Primary

Measure	Time frame
1. intestinal and buccal blood flow and frequency 2. intestinal and buccal relative hemoglobin	—

Secondary

Measure	Time frame
1. Relative intestinal saturation 2. relative buccal Saturation 3. Endothelin I Expression 4. Energy equivalent pressure	—

Countries

Germany

Contacts

Public ContactAndreas Böning

Klinik für Herz-, Kinderherz- und Gefäßchirurgie

Andreas.Böning@chiru.med.uni-giessen.de0641 985 44301

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026