Coma Outcome in Early Neurological Rehabilitation: A Prospective Registry of Long-Term Outcome in Patients with Severe Disorders of Consciousness After Acute Brain Injury

Coma Outcome in Early Neurological Rehabilitation: A Prospective Registry of Long-Term Outcome in Patients with Severe Disorders of Consciousness After Acute Brain Injury - KOPF-R

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00009609

Enrollment

150

Registered

2015-12-02

Start date

2010-09-13

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

R40.2

Interventions

Group 1: In order to determine longterm outcome factors, we examine caregivers and patients with severe disorders of consciousness after acute brain injury within the framework of a multicenter prospe

Eligibility

Sex/Gender

All

Age

18 Years to 82 Years

Inclusion criteria

Inclusion criteria: Acute brain injury as for the referral to a rehabilitation facility. A disorder of consciousness at admission, defined as coma, vegetative state or MCS (based on the Coma Recovery Scale - Revised scores). Written informed consent from caregivers or legal guardian. Patient/Caregiver/Legal Guardian have a sufficient command of the German language and place of residence in Germany.

Exclusion criteria

Exclusion criteria: Application of continuous intravenous sedative drugs (e.g., benzodiazepines, propofol) for artificial coma

Design outcomes

Primary

Measure	Time frame
Long-term outcome (after 6, 12, 24, 36 months) of initially comatose patients with a severe brain injury that considers functional status, quality of life and life participation, after they had used consistently neurorehabilitative options available to them.	—

Secondary

Measure	Time frame
The prognostic value of neurorehabilitation factors in the prediction of a long-term outcome and the psychosocial situation of caregivers.	—

Countries

Germany

Contacts

Public ContactAndreas Bender

Neurologische Klinik, Klinikum der LMU München

Andreas.Bender@med.uni-muenchen.de089-4400-75824

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026