The effect of a ketogenic diet (KD) - a very low carbohydrate and high-fat diet - without caloric restrictions on endurance capacity in healthy adults.

The effect of a ketogenic diet (KD) - a very low carbohydrate and high-fat diet - without caloric restrictions on endurance capacity in healthy adults. - KetoPerformance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00009605

Enrollment

Registered

2016-01-08

Start date

2016-02-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy participants

Interventions

Group 1: ketogenic and eucalroic diet [a very low carbohydrate (<30-40 g/day), high-fat (75%-85% of energy intake) and adequate-protein diet], 6 weeks

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: •?Age >18 years •?Body mass index 19-30 kg/m2 •?Weight loss 50 ml/min) •?Adequate liver function: bilirubin = 1.5 x upper limit of normal (UNL) range, ALAT and/or ASAT = 2.5 x UNL, Alkaline Phosphatase =5 x UNL •?Written informed consent

Exclusion criteria

Exclusion criteria: • Known G6PD (glucose-6-phosphate dehydrogenase) deficiency • Diabetes mellitus undergoing therapy with insulin or oral agents • Kidney stones • Pregnant or lactating women • Disorders of fatty acid metabolism: carnitine deficiency (primary), carnitine palmitoyltransferase (CPT) I or II deficiency, carnitine translocase deficiency, ß-oxidation defects, short-chain acyl dehydrogenase deficiency (SCAD), medium-chain acyl dehydrogenase deficiency (MCAD), long-chain acyl dehydrogenase deficiency (LCAD), medium-chain 3-hydroxyacyl-CoA deficiency, long-chain 3-hydroxyacyl-CoA deficiency, pyruvate carboxylase deficiency, porphyria

Design outcomes

Primary

Measure	Time frame
Endurance capacity [Maximum rate of oxygen consumption - VO2max (mL/kg*min)] via cycle ergometer (before and after 6 weeks of ketogenic diet)	—

Secondary

Measure	Time frame
All secondary endpoints will be measured before and after 6 weeks of ketogenic diet. - Physical strength (Maximum strength of upper leg muscles) via isokinetic test system - Basal metabolic rate (respiratory quotient) via indirect calorimetry - Body composition (Fat and fat-free mass) via whole-Body Air Displacement Plethysmography - Laboratory values (serum): liver function, renal function and fasting lipid profile, ketone bodies, glucose, insulin, IGF-1, CRP - Metabolic parameters (urine): ketone bodies via reagent strips	—

Measure

Time frame

All secondary endpoints will be measured before and after 6 weeks of ketogenic diet. - Physical strength (Maximum strength of upper leg muscles) via isokinetic test system - Basal metabolic rate (respiratory quotient) via indirect calorimetry - Body composition (Fat and fat-free mass) via whole-Body Air Displacement Plethysmography - Laboratory values (serum): liver function, renal function and fasting lipid profile, ketone bodies, glucose, insulin, IGF-1, CRP - Metabolic parameters (urine): ketone bodies via reagent strips

—

Countries

Germany

Contacts

Public ContactPaul Urbain

Universitätsklinikum Freiburg; Klinik für Innere medizin I; Hämatologie, Onkologie und Stammzelltransplantation; Sektion Ernährungsmedizin und Diätetik

paul.urbain@uniklinik-freiburg.de076127033600

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 10, 2026