Liver Failure, Immunosupression, Cyclosporin
Conditions
Interventions
Group 1: Patients with preoperative MELD (Model for End Stage Liver Disease) score of 6-10:
On days 3 and 7 after liver transplantation immediately before and 2 h after cyclosporine A administration
Sponsors
Universitätsklinikum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - First Transplantation -Immunosupression with low-dose CyA+Corticosteroid+MMF (Mycophenolatmofetil) -Operation und postoperative treatment in the university clinic of surgery of heidelberg -Patients treated with cyclosporine
Exclusion criteria
Exclusion criteria: - No IC - Re-Transplantation - acute Infection (CMV pp65 positive, Pneumonia, UTI, wound infection, reactivated hepatitis B/C) - patients not able to receive oral CyA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Validation of expression of the NFAT regulated genes (using PCR Expression Analysis) under treatment with a low dose immunosupression regimen CyA | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between CyA levels and supression of the nfat genes in the time Frame of 2 hours after Administration of CyA. Correlation of nfat regulated genes in patients with stable immunosupression Regimen on the one hand and patients' in the first week after LTx under low-dose CyA Immunosupression. | — |
Countries
Germany
Contacts
Public ContactPhilipp Houben
Klinik für Allgemein-, Viszeral- und Transplantationschirurgie
Outcome results
None listed